{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:21:45Z","timestamp":1783182105644,"version":"3.54.6"},"reference-count":62,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Although\n            <jats:italic>Candida dubliniensis<\/jats:italic>\n            is a close genetic relative of\n            <jats:italic>Candida albicans<\/jats:italic>\n            , it colonizes and infects fewer sites. Nearly all instances of candidiasis caused by\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            are restricted to the oral cavity. As cell surface hydrophobicity (CSH) influences virulence of\n            <jats:italic>C. albicans<\/jats:italic>\n            , CSH properties of\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            were investigated and compared to\n            <jats:italic>C. albicans<\/jats:italic>\n            . Growth temperature is one factor which affects the CSH status of stationary-phase\n            <jats:italic>C. albicans<\/jats:italic>\n            . However,\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            , similar to other pathogenic non-albicans species of\n            <jats:italic>Candida<\/jats:italic>\n            , was hydrophobic regardless of growth temperature. For all\n            <jats:italic>Candida<\/jats:italic>\n            species tested in this study (\n            <jats:italic>C. albicans, C. dubliniensis, C. glabrata, C. krusei, C. parapsilosis<\/jats:italic>\n            , and\n            <jats:italic>C. tropicalis<\/jats:italic>\n            ), CSH status correlated with coaggregation with the anaerobic oral bacterium\n            <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n            . Previous studies have shown that CSH status of\n            <jats:italic>C. albicans<\/jats:italic>\n            involves multiple surface proteins and surface protein N-glycans. The hydrophobic surface glycoprotein CAgp38 appears to be expressed by\n            <jats:italic>C. albicans<\/jats:italic>\n            constitutively regardless of growth temperature and medium.\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            expresses a 38-kDa protein that cross-reacts with the anti-CAgp38 monoclonal antibody; however, expression of the protein was growth medium and growth temperature dependent. The anti-CAgp38 monoclonal antibody has been shown to inhibit adhesion of\n            <jats:italic>C. albicans<\/jats:italic>\n            to extracellular matrix proteins and to vascular endothelial cells. Since protein glycosylation influences the CSH status of\n            <jats:italic>C. albicans<\/jats:italic>\n            , we compared the cell wall mannoprotein content and composition between\n            <jats:italic>C. albicans<\/jats:italic>\n            and\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            . Similar bulk compositional levels of hexose, phosphate, and protein in their N-glycans were determined. However, a component of the\n            <jats:italic>C. albicans<\/jats:italic>\n            N-glycan, acid-labile phosphooligomannoside, is expressed much less or negligibly by\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            , and when present, the oligomannosides are predominantly less than five mannose residues in length. In addition, the acid-labile phosphooligomannoside profiles varied among the three strains of\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            we tested, indicating the N-glycan of\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            differs from\n            <jats:italic>C. albicans<\/jats:italic>\n            . For\n            <jats:italic>C. albicans<\/jats:italic>\n            , the acid-labile phosphooligomannoside influences virulence and surface fibrillar conformation, which affects exposure of hydrophobic surface proteins. Given the combined role in\n            <jats:italic>C. albicans<\/jats:italic>\n            of expression of specific surface hydrophobic proteins in pathogenesis and of surface protein glycosylation on exposure of the proteins, the lack of these virulence-associated CSH entities in\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            could contribute to its limited ability to cause disseminated infections.\n          <\/jats:p>","DOI":"10.1128\/iai.69.2.779-786.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:01:19Z","timestamp":1027764079000},"page":"779-786","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":55,"title":["Comparison of the Hydrophobic Properties of\n            <i>Candida albicans<\/i>\n            and\n            <i>Candida dubliniensis<\/i>"],"prefix":"10.1128","volume":"69","author":[{"given":"Kevin C.","family":"Hazen","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Departments of Pathology1 and"},{"name":"<!--label omitted: 2-->Microbiology,2 University of Virginia Health System, Charlottesville, Virginia 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean G.","family":"Wu","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departments of Pathology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Masuoka","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departments of Pathology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.56.11.2884-2890.1988"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0601.000108"},{"key":"e_1_3_2_4_2","first-page":"234","article-title":"Identification of Candida dubliniensis in a study of HIV-seropositive pediatric dental patients","volume":"22","author":"Brown D. 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