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No significant difference in the distribution of the 10 studied regions was found between the cases and the controls. Nine strains did not harbor any of the selected regions: eight (30.8%) isolated from patients with gastritis only and one (5.9%) from a patient with gastric carcinoma. No association was found between the number of repeated sequences at the 3\u2032 end of the\n            <jats:italic>cagA<\/jats:italic>\n            gene or the presence of tyrosine phosphorylation motifs and the clinical origin of the strains. The\n            <jats:italic>virB10<\/jats:italic>\n            homolog gene was the sole gene studied to be significantly expressed more often in cancer strains than in gastritis strains (\n            <jats:italic>P<\/jats:italic>\n            = 0.03).\n          <\/jats:p>","DOI":"10.1128\/iai.69.3.1902-1908.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:01:19Z","timestamp":1027764079000},"page":"1902-1908","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":51,"title":["Composition and Gene Expression of the\n            <i>cag<\/i>\n            Pathogenicity Island in\n            <i>Helicobacter pylori<\/i>\n            Strains Isolated from Gastric Carcinoma and Gastritis Patients in Costa Rica"],"prefix":"10.1128","volume":"69","author":[{"given":"Alessandra","family":"Occhialini","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Bacte\u0301riologie, Universite\u0301 Victor Se\u0301galen Bordeaux 2 et Ho\u0302pital Pellegrin, 33076 Bordeaux,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armelle","family":"Marais","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Bacte\u0301riologie, Universite\u0301 Victor Se\u0301galen Bordeaux 2 et Ho\u0302pital Pellegrin, 33076 Bordeaux,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Urdaci","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Laboratoire de Microbiologie, Ecole Nationale d'Inge\u0301nieurs des Travaux Agricoles, 33170 Gradignan,2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela","family":"Sierra","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->University of Costa Rica, San Jose\u0301, Costa Rica;3 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nubia","family":"Mun\u0303oz","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Centre International de Recherche sur le Cancer, 69372 Lyon,4 France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Covacci","sequence":"additional","affiliation":[{"name":"<!--label omitted: 5-->IRIS, 53100 Siena, Italy5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Me\u0301graud","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Bacte\u0301riologie, Universite\u0301 Victor Se\u0301galen Bordeaux 2 et Ho\u0302pital Pellegrin, 33076 Bordeaux,1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01382.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00770.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/16495"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.4.593"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.25.14648"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(97)01035-4"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.63.3.675-707.1999"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/35006081"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8465"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70422-6"},{"key":"e_1_3_2_12_2","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans Helicobacter pylori Schistosomes liver flukes and Helicobacter pylori: views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.\n1994\n177\n240\nIARC\nLyon France"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65343-6"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.6.752"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01140.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70155-0"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.3.336"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.63.3.642-674.1999"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"e_1_3_2_20_2","first-page":"1190","article-title":"Helicobacter pylori and gastric cancer","volume":"84","author":"McFarlane G. 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