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Using a SCID mouse model of<jats:italic>Pneumocystis carinii<\/jats:italic>pneumonia, we were able to demonstrate protection against an airborne challenge with<jats:italic>P. carinii<\/jats:italic>by intranasal administration of antibody. Immunoglobulin M (IgM) monoclonal antibodies to an epitope shared by mouse and human<jats:italic>P. carinii<\/jats:italic>organisms reduced organism numbers by more than 99% under the conditions described. An IgG1 switch variant of one of the IgM monoclonal antibodies was also protective. These experiments provide a model for exploring the utility of this approach in protecting at-risk patients from infection with<jats:italic>P. carinii<\/jats:italic>.<\/jats:p>","DOI":"10.1128\/iai.70.3.1069-1074.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:56:57Z","timestamp":1027763817000},"page":"1069-1074","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":86,"title":["Passive Intranasal Monoclonal Antibody Prophylaxis against Murine<i>Pneumocystis carinii<\/i>Pneumonia"],"prefix":"10.1128","volume":"70","author":[{"given":"Francis","family":"Gigliotti","sequence":"first","affiliation":[{"name":"Department of Pediatrics"},{"name":"Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine G.","family":"Haidaris","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry W.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen G.","family":"Harmsen","sequence":"additional","affiliation":[{"name":"the Trudeau Institute, Saranac Lake, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.5.1.74-77.1998"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196905292802201"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.7.2619-2624.1995"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.6.1892-1899.1996"},{"key":"e_1_3_2_6_2","first-page":"313","volume":"13","year":"1998","unstructured":"Gigliotti, F., and C. 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