{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:21:06Z","timestamp":1790925666656,"version":"4.1.0"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>T-cell proliferative responses were studied in two villages in Gabon with different levels of<jats:italic>Loa loa<\/jats:italic>transmission. The first village (Okoumbi) had an annual transmission potential (ATP) of \u22489,000 infective larvae (L3)\/person\/year (high transmission village), while the second village (Ndjokaye) had an ATP of \u22481,000 L3\/person\/year (low transmission village). Proliferation and cytokine assays were performed on peripheral blood mononuclear cells (PBMC) from individuals aged 18 years and over using either mitogens (concanavalin A or phytohemagglutinin), antigens (purified protein derivative [PPD], irrelevant antigen), or soluble extracts of L3, microfilariae, or adult<jats:italic>L. loa<\/jats:italic>. PBMC from individuals in the low transmission village responded better to stimulation with adult antigen and to PPD than did PBMC from individuals in the high transmission village (<jats:italic>P<\/jats:italic>= 0.0031 and<jats:italic>P<\/jats:italic>= 0.0012, respectively). These data suggest that high levels of transmission of<jats:italic>L. loa<\/jats:italic>depress both specific and nonspecific T-cell proliferative responses in infected humans.<\/jats:p>","DOI":"10.1128\/iai.70.3.1475-1480.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:58:35Z","timestamp":1027763915000},"page":"1475-1480","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Transmission Intensity Affects Both Antigen-Specific and Nonspecific T-Cell Proliferative Responses in<i>Loa loa<\/i>Infection"],"prefix":"10.1128","volume":"70","author":[{"given":"Jean Paul","family":"Akue","sequence":"first","affiliation":[{"name":"Department of Medical Parasitology, International Center for Medical Research of Franceville (CIRMF), BP 769, Franceville, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Devaney","sequence":"additional","affiliation":[{"name":"Department of Veterinary Parasitology, University of Glasgow, Glasgow G61 1QH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"246","volume":"45","year":"1994","unstructured":"Akue, J. 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