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The efficacy of KT MAbs against<jats:italic>Aspergillus fumigatus<\/jats:italic>was investigated in a mouse model of T-cell-depleted allogeneic bone marrow transplantation (BMT) with invasive pulmonary aspergillosis. Mice were highly susceptible to infection at 3 days post-BMT, when profound neutropenia was observed both in the periphery and in the lungs. Treatment with KT MAbs protected the mice from infection, as judged by the long-term survival and decreased pathology associated with inhibition of fungal growth and hyphal development in the lungs. In vitro, similar to polymorphonuclear neutrophils, KT MAbs significantly inhibited the hyphal development and metabolic activity of germinated<jats:italic>Aspergillus<\/jats:italic>conidia. These results indicate that mimicking the action of neutrophils could be a strategy through which KT MAbs exert therapeutic efficacy in<jats:italic>A. fumigatus<\/jats:italic>infections.<\/jats:p>","DOI":"10.1128\/iai.70.5.2375-2382.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:09:01Z","timestamp":1027764541000},"page":"2375-2382","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":59,"title":["Protection of Killer Antiidiotypic Antibodies against Early Invasive Aspergillosis in a Murine Model of Allogeneic T-Cell-Depleted Bone Marrow Transplantation"],"prefix":"10.1128","volume":"70","author":[{"given":"Elio","family":"Cenci","sequence":"first","affiliation":[{"name":"Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Mencacci","sequence":"additional","affiliation":[{"name":"Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Spreca","sequence":"additional","affiliation":[{"name":"Anatomy Sections, Department of Experimental Medicine and Biochemical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Montagnoli","sequence":"additional","affiliation":[{"name":"Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Bacci","sequence":"additional","affiliation":[{"name":"Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Perruccio","sequence":"additional","affiliation":[{"name":"Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Velardi","sequence":"additional","affiliation":[{"name":"Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Magliani","sequence":"additional","affiliation":[{"name":"Microbiology Section, Department of Pathology and Laboratory Medicine, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Conti","sequence":"additional","affiliation":[{"name":"Microbiology Section, Department of Pathology and Laboratory Medicine, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Polonelli","sequence":"additional","affiliation":[{"name":"Microbiology Section, Department of Pathology and Laboratory Medicine, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigina","family":"Romani","sequence":"additional","affiliation":[{"name":"Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.9.2310-2318.2000"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.4.2037-2044.2001"},{"key":"e_1_3_2_4_2","first-page":"1268","volume":"12","year":"1995","unstructured":"Bachar-Lustig, E., N. 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