{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:55:40Z","timestamp":1791006940603,"version":"4.1.0"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>To understand the role of interleukin-10 (IL-10) in ocular toxoplasmosis, we compared C57BL\/6 (B6) and BALB\/c background mice lacking a functional IL-10 gene (IL-10<jats:sup>\u2212\/\u2212<\/jats:sup>) and B6 transgenic mice expressing IL-10 under the control of the IL-2 promoter. Increased cellular infiltration and necrosis were observed in the eye tissue of IL-10<jats:sup>\u2212\/\u2212<\/jats:sup>mice of both the B6 and BALB\/c backgrounds with associated changes in the levels of cytokines in serum. In contrast, there was no evidence of necrosis in the eye tissue from IL-10 transgenic mice following parasite exposure. Our results demonstrate that IL-10 is important in the regulation of inflammation during acute ocular toxoplasmosis.<\/jats:p>","DOI":"10.1128\/iai.71.12.7159-7163.2003","type":"journal-article","created":{"date-parts":[[2003,11,25]],"date-time":"2003-11-25T01:34:54Z","timestamp":1069724094000},"page":"7159-7163","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["Interleukin-10 and Pathogenesis of Murine Ocular Toxoplasmosis"],"prefix":"10.1128","volume":"71","author":[{"given":"Fangli","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Medicine and Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756"},{"name":"Sun Yat-sen University School of Medicine, Guangzhou 510089"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiguang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medicine and Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756"},{"name":"Jinan University School of Medicine, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd H.","family":"Kasper","sequence":"additional","affiliation":[{"name":"Department of Medicine and Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(92)90082-P"},{"key":"e_1_3_2_3_2","first-page":"745","volume":"31","year":"2001","unstructured":"el-Malky, B. 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