{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:23:25Z","timestamp":1759047805684},"reference-count":25,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemokine concentrations and a more pronounced infiltrate, but antibacterial defense or survival was not influenced.<\/jats:p>","DOI":"10.1128\/iai.71.4.2276-2279.2003","type":"journal-article","created":{"date-parts":[[2003,3,24]],"date-time":"2003-03-24T23:07:27Z","timestamp":1048547247000},"page":"2276-2279","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Interleukin-10 Negatively Regulates Local Cytokine and Chemokine Production but Does Not Influence Antibacterial Host Defense during Murine Pneumococcal Meningitis"],"prefix":"10.1128","volume":"71","author":[{"given":"Petra J. G.","family":"Zwijnenburg","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Vrije Universiteit Medical Center"},{"name":"Departments of Experimental Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"van der Poll","sequence":"additional","affiliation":[{"name":"Departments of Experimental Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Florquin","sequence":"additional","affiliation":[{"name":"Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Roord","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Vrije Universiteit Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Marceline","family":"van Furth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Vrije Universiteit Medical Center"},{"name":"Departments of Experimental Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"398","volume":"114","year":"1998","unstructured":"Bakhiet, M., M. Mustafa, J. Zhu, R. Harris, L. Lindquist, H. Link, and A. Diab. 1998. Induction of cytokines and anti-cytokine autoantibodies in cerebrospinal fluid (CSF) during experimental bacterial meningitis. Clin. Exp. Immunol.114:398-402.","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Bradley J. S. and W. M. Scheld. 1997. The challenge of penicillin-resistant Streptococcus pneumoniae meningitis: current antibiotic therapy in the 1990s. Clin. Infect. Dis. 24 (Suppl. 2) : S213-S221.","DOI":"10.1093\/clinids\/24.Supplement_2.S213"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510470035031"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/517344"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.7.4561-4571.2001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90093-0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90153-X"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199610000-00016"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"5185","DOI":"10.4049\/jimmunol.157.11.5185","volume":"157","year":"1996","unstructured":"Koedel, U., A. Bernatowicz, K. Frei, A. Fontana, and H. W. Pfister. 1996. Systemically (but not intrathecally) administered IL-10 attenuates pathophysiologic alterations in experimental pneumococcal meningitis. J. Immunol.157:5185-5191.","journal-title":"J. Immunol."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/173.6.1498"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1996.tb00084.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1997.4367"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1136(200102)33:2<97::AID-GLIA1009>3.0.CO;2-N"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.11.040193.001121"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/21202"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/515032"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.18.8676"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.4049\/jimmunol.158.8.3971","volume":"158","year":"1997","unstructured":"Pajkrt, D., L. Camoglio, M. C. Tiel-van Buul, K. de Bruin, D. L. Cutler, M. B. Affrime, G. Rikken, T. van der Poll, J. W. ten Cate, and S. J. van Deventer. 1997. Attenuation of proinflammatory response by recombinant human IL-10 in human endotoxemia: effect of timing of recombinant human IL-10 administration. J. Immunol.158:3971-3977.","journal-title":"J. Immunol."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/514118"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1046\/j.1471-4159.1999.721466.x","volume":"72","year":"1999","unstructured":"Sawada, M., A. Suzumura, H. Hosoya, T. Marunouchi, and T. Nagatsu. 1999. Interleukin-10 inhibits both production of cytokines and expression of cytokine receptors in microglia. J. Neurochem.72:1466-1471.","journal-title":"J. Neurochem."},{"key":"e_1_3_2_22_2","first-page":"427","volume":"21","year":"2001","unstructured":"Strle, K., J. H. Zhou, W. H. Shen, S. R. Broussard, R. W. Johnson, G. G. Freund, R. Dantzer, and K. W. Kelley. 2001. Interleukin-10 in the brain. Crit. Rev. Immunol.21:427-449.","journal-title":"Crit. Rev. Immunol."},{"key":"e_1_3_2_23_2","first-page":"403","volume":"43","year":"1998","unstructured":"Townsend, G. C., and W. M. Scheld. 1998. Infections of the central nervous system. Adv. Intern. Med.43:403-447.","journal-title":"Adv. Intern. Med."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.5.994"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.1.220"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1086\/319271"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.71.4.2276-2279.2003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.71.4.2276-2279.2003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T14:28:12Z","timestamp":1704810492000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.71.4.2276-2279.2003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["10.1128\/IAI.71.4.2276-2279.2003"],"URL":"https:\/\/doi.org\/10.1128\/iai.71.4.2276-2279.2003","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4]]},"assertion":[{"value":"2002-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-12-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}