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An orthologous gene cluster has recently been detected in\n            <jats:italic>Escherichia coli<\/jats:italic>\n            strains which cause extraintestinal disease. This\n            <jats:italic>E. coli iroBCDEN<\/jats:italic>\n            gene cluster has an impact on virulence and has been reported to be located in a pathogenicity island on the chromosome. In this study we characterized an\n            <jats:italic>iro<\/jats:italic>\n            gene cluster of a uropathogenic\n            <jats:italic>E. coli<\/jats:italic>\n            isolate which is located on a transmissible plasmid related to the R64 plasmid of\n            <jats:italic>S. enterica<\/jats:italic>\n            . This cluster is highly homologous to the chromosomal\n            <jats:italic>iro<\/jats:italic>\n            cluster of\n            <jats:italic>E. coli<\/jats:italic>\n            . When introduced into an\n            <jats:italic>E. coli fepA cir fiu aroB<\/jats:italic>\n            mutant, IroN, but not IroBCDE, mediated the utilization of structurally related catecholate siderophores, including 2,3-dihydroxybenzoyl-\n            <jats:sc>l<\/jats:sc>\n            -serine, 2,3-dihydroxybenzoyl-\n            <jats:sc>d<\/jats:sc>\n            -ornithine, 2,3-dihydroxybenzoic acid, and enterochelin. This study supports the idea of an ongoing horizontal transfer of putative virulence factors and the mobilization of single virulence gene clusters, which lead to a modular assembly of virulence determinants such as pathogenicity islands.\n          <\/jats:p>","DOI":"10.1128\/iai.71.6.3285-3293.2003","type":"journal-article","created":{"date-parts":[[2003,5,21]],"date-time":"2003-05-21T23:33:12Z","timestamp":1053559992000},"page":"3285-3293","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":72,"title":["Characterization of an\n            <i>iroBCDEN<\/i>\n            Gene Cluster on a Transmissible Plasmid of Uropathogenic\n            <i>Escherichia coli<\/i>\n            : Evidence for Horizontal Transfer of a Chromosomal Virulence Factor"],"prefix":"10.1128","volume":"71","author":[{"given":"Liisa Johanna","family":"Sorsa","sequence":"first","affiliation":[{"name":"Max von Pettenkofer-Institut fu\u0308r Hygiene und Medizinische Mikrobiologie, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Severin","family":"Dufke","sequence":"additional","affiliation":[{"name":"Max von Pettenkofer-Institut fu\u0308r Hygiene und Medizinische Mikrobiologie, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u0308rgen","family":"Heesemann","sequence":"additional","affiliation":[{"name":"Max von Pettenkofer-Institut fu\u0308r Hygiene und Medizinische Mikrobiologie, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So\u0308ren","family":"Schubert","sequence":"additional","affiliation":[{"name":"Max von Pettenkofer-Institut fu\u0308r Hygiene und Medizinische Mikrobiologie, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_3_2_4_2","unstructured":"Ausubel F. 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