{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:33:25Z","timestamp":1790696005992,"version":"4.1.0"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2004,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Salmonella enterica<\/jats:italic>\n serovar Typhi uses type IVB pili to facilitate bacterial self-association, but only when the PilV proteins (potential minor pilus proteins) are not synthesized. This pilus-mediated event may be important in typhoid fever pathogenesis. We initially show that\n S. enterica<\/jats:italic>\n serovar Paratyphi C strains harbor a\n pil<\/jats:italic>\n operon very similar to that of serovar Typhi. An important difference, however, is located in the shufflon which concludes the\n pil<\/jats:italic>\n operon. In serovar Typhi, the Rci recombinase acts upon two 19-bp inverted repeats to invert the terminal region of the\n pilV<\/jats:italic>\n gene, thereby disrupting PilV synthesis and permitting bacterial self-association. In serovar Paratyphi C, however, the shufflon is essentially inactive because each of the Rci 19-bp substrates has acquired a single base pair insertion. A PilV protein is thus synthesized whenever the\n pil<\/jats:italic>\n operon is active, and bacterial self-association therefore does not occur in serovar Paratyphi C. The data thus suggest that serovar Typhi bacterial self-association using type IVB pili may be important in the pathogenesis of epidemic enteric fever.\n <\/jats:p>","DOI":"10.1128\/iai.72.1.22-28.2004","type":"journal-article","created":{"date-parts":[[2003,12,20]],"date-time":"2003-12-20T02:48:22Z","timestamp":1071888502000},"page":"22-28","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Salmonella enterica<\/i>\n Serovar Paratyphi C Carries an Inactive Shufflon"],"prefix":"10.1128","volume":"72","author":[{"given":"Connie K. P.","family":"Tam","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Hackett","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.11.6196-6205.2002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.10.2787-2792.2000"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00195-X"},{"key":"e_1_3_2_5_2","unstructured":"Kauffman F. 1961. 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