{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:06:43Z","timestamp":1760954803053},"reference-count":13,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Transcutaneous immunization of mice with recombinant protective antigen (rPA) of\n            <jats:italic>Bacillus anthracis<\/jats:italic>\n            resulted in significantly higher lethal toxin-neutralizing antibody titers than did intramuscular injection of alum-adsorbed rPA. Immunized mice were partially protected against intranasal challenge with 235,000 (10 50% lethal doses) Ames strain\n            <jats:italic>B. anthracis<\/jats:italic>\n            spores. A highly significant correlation was observed between toxin-neutralizing antibody titer and survival after challenge. Future experiments with rabbits and nonhuman primates should confirm the significance of protection by this vaccine strategy.\n          <\/jats:p>","DOI":"10.1128\/iai.74.1.794-797.2006","type":"journal-article","created":{"date-parts":[[2005,12,20]],"date-time":"2005-12-20T22:02:58Z","timestamp":1135116178000},"page":"794-797","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":48,"title":["Correlation between Lethal Toxin-Neutralizing Antibody Titers and Protection from Intranasal Challenge with\n            <i>Bacillus anthracis<\/i>\n            Ames Strain Spores in Mice after Transcutaneous Immunization with Recombinant Anthrax Protective Antigen"],"prefix":"10.1128","volume":"74","author":[{"given":"Kristina K.","family":"Peachman","sequence":"first","affiliation":[{"name":"Department of Vaccine Production and Delivery, Division of Retrovirology, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland 20850"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mangala","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Vaccine Production and Delivery, Division of Retrovirology, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland 20850"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl R.","family":"Alving","sequence":"additional","affiliation":[{"name":"Department of Vaccine Production and Delivery, Division of Retrovirology, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland 20850"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Burge","sequence":"additional","affiliation":[{"name":"Division of Biometrics, Walter Reed Army Institute of Research, Silver Spring, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen H.","family":"Leppla","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venigalla B.","family":"Rao","sequence":"additional","affiliation":[{"name":"The Catholic University of America, Washington, D.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary R.","family":"Matyas","sequence":"additional","affiliation":[{"name":"Department of Vaccine Production and Delivery, Division of Retrovirology, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland 20850"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600495"},{"key":"e_1_3_2_3_2","first-page":"33","volume":"271","year":"2002","unstructured":"Friedlander, A. 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