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We have developed a custom-made guinea pig oligonucleotide microarray (81 spots) and have examined the gene expression profile of splenocytes restimulated in vitro from<jats:italic>Mycobacterium bovis<\/jats:italic>BCG-vaccinated and naive animals. Eleven genes were significantly (<jats:italic>P<\/jats:italic>&lt; 0.05) up-regulated following vaccination, indicating a Th1-type response. 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