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Since this species is an important member of the oral flora, we examined the direct binding of these adhesins to human salivary proteins. Both GspB and Hsa bound low-molecular-weight salivary mucin MG2 and salivary agglutinin. Hsa also bound several other salivary proteins, including secretory immunoglobulin A. Screening of six oral streptococcal isolates revealed that at least two of the strains expressed GspB homologues. These results indicate that GspB-like adhesins may be important for oral bacterial colonization.\n          <\/jats:p>","DOI":"10.1128\/iai.74.3.1933-1940.2006","type":"journal-article","created":{"date-parts":[[2006,2,23]],"date-time":"2006-02-23T00:18:14Z","timestamp":1140653894000},"page":"1933-1940","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":89,"title":["Binding of the Streptococcal Surface Glycoproteins GspB and Hsa to Human Salivary Proteins"],"prefix":"10.1128","volume":"74","author":[{"given":"Daisuke","family":"Takamatsu","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Veterans Affairs Medical Center"},{"name":"Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Bensing","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Veterans Affairs Medical Center"},{"name":"Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akraporn","family":"Prakobphol","sequence":"additional","affiliation":[{"name":"Department of Cell and Tissue Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Cell and Tissue Biology"},{"name":"Departments of Anatomy, Pharmaceutical Chemistry, and Obstetric, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Sullam","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Veterans Affairs Medical Center"},{"name":"Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(02)00171-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.11.6528-6537.2004"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1373-1380.2001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04919.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.02949.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150170116"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)39087-8"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.42.3.1006-1012.1983"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.29.100175.000315"},{"key":"e_1_3_2_11_2","first-page":"62","volume":"6","year":"1980","unstructured":"Gibbons, R. 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