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Here we employed comparative genomic hybridization to investigate 11 strains of\n            <jats:italic>E. coli<\/jats:italic>\n            K1 isolated from the cerebrospinal fluid (CSF) of patients with meningitis. These 11 strains cover the majority of common O serotypes in\n            <jats:italic>E. coli<\/jats:italic>\n            K1 isolates from CSF. Our data demonstrated that these 11 strains of\n            <jats:italic>E. coli<\/jats:italic>\n            K1 can be categorized into two groups based on their profile for putative virulence factors, lipoproteins, proteases, and outer membrane proteins. Of interest, we showed that some open reading frames (ORFs) encoding the type III secretion system apparatus were found in group 2 strains but not in group 1 strains, while ORFs encoding the general secretory pathway are predominant in group 1 strains. These findings suggest that\n            <jats:italic>E. coli<\/jats:italic>\n            K1 strains isolated from CSF can be divided into two groups and these two groups of\n            <jats:italic>E. coli<\/jats:italic>\n            K1 may utilize different mechanisms to induce meningitis.\n          <\/jats:p>","DOI":"10.1128\/iai.74.4.2196-2206.2006","type":"journal-article","created":{"date-parts":[[2006,3,21]],"date-time":"2006-03-21T23:12:50Z","timestamp":1142982770000},"page":"2196-2206","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Genomic Comparison of\n            <i>Escherichia coli<\/i>\n            K1 Strains Isolated from the Cerebrospinal Fluid of Patients with Meningitis"],"prefix":"10.1128","volume":"74","author":[{"given":"Yufeng","family":"Yao","sequence":"first","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, School of Medicine, Johns Hopkins University, 600 North Wolfe St., Park 256, Baltimore, Maryland 21287"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Xie","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, School of Medicine, Johns Hopkins University, 600 North Wolfe St., Park 256, Baltimore, Maryland 21287"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, School of Medicine, Johns Hopkins University, 600 North Wolfe St., Park 256, Baltimore, Maryland 21287"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01191.x"},{"key":"e_1_3_2_3_2","unstructured":"Ausubel F. 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