{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:28:07Z","timestamp":1768562887830,"version":"3.49.0"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"17","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R37 AI83256"],"award-info":[{"award-number":["R37 AI83256"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"MINCyT | Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2013-0092"],"award-info":[{"award-number":["PICT 2013-0092"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 0092"],"award-info":[{"award-number":["PIP 0092"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003947","name":"Universidad Nacional de La Plata","doi-asserted-by":"publisher","award":["Doctoral fellowship"],"award-info":[{"award-number":["Doctoral fellowship"]}],"id":[{"id":"10.13039\/501100003947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>\n            Pathogenesis of\n            <jats:italic>Bordetella<\/jats:italic>\n            spp., like that of a number of other pathogens, involves biofilm formation. Biofilms increase tolerance to biotic and abiotic factors and are proposed as reservoirs of microbes for transmission to other organs (trachea, lungs) or other hosts. Bis-(3\u2032-5\u2032)-cyclic dimeric GMP (c-di-GMP) is a second messenger that regulates transition between biofilm and planktonic lifestyles. In\n            <jats:named-content content-type=\"genus-species\">Bordetella bronchiseptica<\/jats:named-content>\n            , high c-di-GMP levels inhibit motility and favor biofilm formation. In the present work, we characterized a\n            <jats:named-content content-type=\"genus-species\">B. bronchiseptica<\/jats:named-content>\n            diguanylate cyclase, BdcA, which regulates motility and biofilm formation and affects the ability of\n            <jats:named-content content-type=\"genus-species\">B. bronchiseptica<\/jats:named-content>\n            to colonize the murine respiratory tract. These results provide us with a better understanding of how\n            <jats:named-content content-type=\"genus-species\">B. bronchiseptica<\/jats:named-content>\n            can infect a host.\n          <\/jats:p>","DOI":"10.1128\/jb.00011-19","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T13:28:38Z","timestamp":1560432518000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Bordetella bronchiseptica Diguanylate Cyclase BdcA Regulates Motility and Is Important for the Establishment of Respiratory Infection in Mice"],"prefix":"10.1128","volume":"201","author":[{"given":"Keila","family":"Belhart","sequence":"first","affiliation":[{"name":"Instituto de Biotecnolog\u00eda y Biolog\u00eda Molecular (IBBM)-CCT-CONICET-La Plata, Departamento de Ciencias Biol\u00f3gicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda de la Paz","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnolog\u00eda y Biolog\u00eda Molecular (IBBM)-CCT-CONICET-La Plata, Departamento de Ciencias Biol\u00f3gicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Zacca","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnolog\u00eda y Biolog\u00eda Molecular (IBBM)-CCT-CONICET-La Plata, Departamento de Ciencias Biol\u00f3gicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00e1s","family":"Ambrosis","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnolog\u00eda y Biolog\u00eda Molecular (IBBM)-CCT-CONICET-La Plata, Departamento de Ciencias Biol\u00f3gicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Cartelle Gestal","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt M.","family":"Dahlstrom","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric T.","family":"Harvill","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A.","family":"O\u2019Toole","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7548-0422","authenticated-orcid":false,"given":"Federico","family":"Sisti","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnolog\u00eda y Biolog\u00eda Molecular (IBBM)-CCT-CONICET-La Plata, Departamento de Ciencias Biol\u00f3gicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7803-5885","authenticated-orcid":false,"given":"Julieta","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnolog\u00eda y Biolog\u00eda Molecular (IBBM)-CCT-CONICET-La Plata, Departamento de Ciencias Biol\u00f3gicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2014.11.010"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.068189-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.190"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.064345-0"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.44.4.722-738.1980"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.17.5692-5698.2004"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.4.1474-1484.2005"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2741\/Mattoo"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006267107"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.8.3381-3390.1994"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.11.3468-3479.1993"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1997.3821741.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049166"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929866525666180628162405"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.08.030"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00090-16"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00785-07"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01373-07"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01418-07"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.018"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.03.001"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C600179200"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158752"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01978-15"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.053"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1454"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004862"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.05483-11"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00703-17"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep32774"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00043-12"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.10.4072-4078.1993"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-63-2-211"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.62.3.293-300.1951"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2005.04.003"}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.00011-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.00011-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T17:48:39Z","timestamp":1627580919000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JB.00011-19"}},"subtitle":[],"editor":[{"given":"Michael Y.","family":"Galperin","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":35,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1128\/JB.00011-19"],"URL":"https:\/\/doi.org\/10.1128\/jb.00011-19","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"2019-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}