{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:12:17Z","timestamp":1789650737030,"version":"4.0.0"},"reference-count":68,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99-DE029228"],"award-info":[{"award-number":["K99-DE029228"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00-DE029228"],"award-info":[{"award-number":["R00-DE029228"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R25-DE032536"],"award-info":[{"award-number":["R25-DE032536"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R25-GM154345"],"award-info":[{"award-number":["R25-GM154345"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35-DE028252"],"award-info":[{"award-number":["R35-DE028252"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2026,9,17]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      The genus\n                      <jats:italic toggle=\"yes\">Streptococcus<\/jats:italic>\n                      contains some of the most important commensals and pathogens of the human microbiome. To obtain the fatty acids required for cell membranes,\n                      <jats:italic toggle=\"yes\">Streptococcus<\/jats:italic>\n                      either produce fatty acids\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      through the fatty acid biosynthesis (\n                      <jats:italic toggle=\"yes\">fab<\/jats:italic>\n                      ) pathway or uptake host fatty acids through the fatty acid kinase (\n                      <jats:italic toggle=\"yes\">fak<\/jats:italic>\n                      ) pathway. Although both the\n                      <jats:italic toggle=\"yes\">fab<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">fak<\/jats:italic>\n                      pathways represent potential therapeutic targets to prevent or treat infection\n                      <jats:italic toggle=\"yes\">,<\/jats:italic>\n                      progress is limited because of an incomplete understanding of taxon-to-taxon variability in streptococcal lipid metabolism. Here, we examined the role of\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      monounsaturated fatty acid (MUFA) synthesis in physiology and virulence-associated traits in\n                      <jats:italic toggle=\"yes\">Streptococcus mutans, Streptococcus pyogenes,<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Streptococcus pneumoniae,<\/jats:italic>\n                      three major pathogens that cause disease at distinct body sites. In all three species, deletion of\n                      <jats:italic toggle=\"yes\">fabM<\/jats:italic>\n                      abolished MUFA production and caused severe growth defects, decreased stress tolerance, increased antibiotic susceptibility, and defects in cell viability, morphology, and division. In\n                      <jats:italic toggle=\"yes\">S. mutans,<\/jats:italic>\n                      loss of\n                      <jats:italic toggle=\"yes\">fabM<\/jats:italic>\n                      also markedly reduced competence signaling and production of the mutacin IV bacteriocin. Deletion of\n                      <jats:italic toggle=\"yes\">fabM<\/jats:italic>\n                      increased susceptibility to killing by human neutrophils in\n                      <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">S. pneumoniae,<\/jats:italic>\n                      but not\n                      <jats:italic toggle=\"yes\">S. pyogenes<\/jats:italic>\n                      . Together, these findings illustrate that MUFA synthesis is broadly important for streptococcal physiology and cell membrane homeostasis, while its contribution to pathogenesis is strongly species- and context-dependent, providing leads to guide the development of novel therapeutic and\/or preventative strategies.\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        <jats:italic toggle=\"yes\">Streptococcus<\/jats:italic>\n                        spp. exert profound effects on human health, with several species causing significant morbidity and mortality. Although streptococcal fatty acid biosynthesis and utilization are attractive metabolic targets for development of therapeutics, this opportunity is vexed by an incomplete understanding of taxon-to-taxon variability in lipid metabolism. In this study, the role of\n                        <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                        monounsaturated fatty acid (MUFA) synthesis in physiology and virulence-associated traits was examined in\n                        <jats:italic toggle=\"yes\">Streptococcus mutans, Streptococcus pyogenes,<\/jats:italic>\n                        and\n                        <jats:italic toggle=\"yes\">Streptococcus pneumoniae,<\/jats:italic>\n                        three major pathogens that cause disease at distinct body sites. MUFA synthesis was important for stress and antibiotic tolerance across all three species, while its impact on virulence was species- and context-dependent. Overall, these discoveries provide leads to guide the development of novel therapeutic and\/or preventative strategies.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/jb.00026-26","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:59:10Z","timestamp":1786114750000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Monounsaturated fatty acid biosynthesis is critical for streptococcal envelope homeostasis and stress tolerance"],"prefix":"10.1128","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5378-322X","authenticated-orcid":true,"given":"Jonathon L.","family":"Baker","sequence":"first","affiliation":[{"name":"Department of Biomaterial & Biomedical Sciences, OHSU School of Dentistry","place":["Portland, USA"]},{"name":"Department of Biomedical Engineering, OHSU School of 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