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Two isogenic serotypes of\n            <jats:italic>Borrelia turicatae<\/jats:italic>\n            strain Oz1 differ in their Vsp sequences and in disease manifestations in infected mice: Vsp1 is associated with the selection of a neurological niche, while Vsp2 is associated with blood and skin infection. We report here crystal structures of the Vsp1 dimer at 2.7 and 2.2 A\u030a. The structures confirm that relapsing fever Vsp proteins share a common helical fold with OspCs of Lyme disease-causing\n            <jats:italic>Borrelia<\/jats:italic>\n            . The fold features an inner stem formed by highly conserved N and C termini and an outer \u201cdome\u201d formed by the variable central residues. Both Vsp1 and OspC structures possess small water-filled cavities, or pockets, that are lined largely by variable residues and are thus highly variable in shape. These features appear to signify tolerance of the Vsp-OspC fold for imperfect packing of residues at its antigenic surface. Structural comparison of Vsp1 with a homology model for Vsp2 suggests that observed differences in disease manifestation may arise in part from distinct differences in electrostatic surface properties; additional predicted positively charged surface patches on Vsp2 compared to Vsp1 may be sufficient to explain the relative propensity of Vsp2 to bind to acidic glycosaminoglycans.\n          <\/jats:p>","DOI":"10.1128\/jb.00028-06","type":"journal-article","created":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T21:31:37Z","timestamp":1149197497000},"page":"4522-4530","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Crystal Structure of Neurotropism-Associated Variable Surface Protein 1 (Vsp1) of\n            <i>Borrelia turicatae<\/i>"],"prefix":"10.1128","volume":"188","author":[{"given":"Catherine L.","family":"Lawson","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian H.","family":"Yung","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan G.","family":"Barbour","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Molecular Genetics and Medicine, University of California at Irvine, College of Medicine, Irvine, California 92697"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram R.","family":"Zu\u0308ckert","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Molecular Genetics and Medicine, University of California at Irvine, College of Medicine, Irvine, California 92697"},{"name":"Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas 66160"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.7883\/yoken1952.26.229","volume":"26","year":"1973","unstructured":"Arimitsu, Y., and K. 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