{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:50:54Z","timestamp":1774327854588,"version":"3.50.1"},"reference-count":78,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2022,5,17]]},"abstract":"<jats:p>\n            Rising antibiotic resistance rates in\n            <jats:named-content content-type=\"genus-species\">H. pylori<\/jats:named-content>\n            are associated with increased rates of treatment failure. Understanding how stressors impact antibiotic resistance may shed light on the development of future treatment strategies.\n          <\/jats:p>","DOI":"10.1128\/jb.00045-22","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T13:01:54Z","timestamp":1649336514000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Interplay between Amoxicillin Resistance and Osmotic Stress in Helicobacter pylori"],"prefix":"10.1128","volume":"204","author":[{"given":"Ian H.","family":"Windham","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7095-5177","authenticated-orcid":true,"given":"D. Scott","family":"Merrell","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/den.12471"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13497"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00844.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-28032016000400002"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/157488508785747899"},{"key":"e_1_3_3_7_2","first-page":"409","article-title":"Worldwide H. pylori antibiotic resistance: a systematic review","volume":"19","author":"De Francesco V","year":"2010","unstructured":"De Francesco V, Giorgio F, Hassan C, Manes G, Vannella L, Panella C, Ierardi E, Zullo A. 2010. Worldwide H. pylori antibiotic resistance: a systematic review. J Gastrointestin Liver Dis 19:409\u2013414.","journal-title":"J Gastrointestin Liver Dis"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn051"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00545-10"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf140"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.3.962-965.2001"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2008.00105.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/9781555818005.ch14"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07791.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.11.2702"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01348-07"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-0366-3"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12724"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.1.11-19.2002"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00366-06"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2006.00418.x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01728-07"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00626-17"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4746"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201400176"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2019.05.002"},{"key":"e_1_3_3_27_2","first-page":"4823","article-title":"High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL\/6 mice","volume":"59","author":"Fox JG","year":"1999","unstructured":"Fox JG, Dangler CA, Taylor NS, King A, Koh TJ, Wang TC. 1999. High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL\/6 mice. Cancer Res 59:4823\u20134828.","journal-title":"Cancer Res"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00918-15"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01271-12"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21810"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/808120"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2013.07.004"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/9781555818005.ch17"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01625.x"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-011-0396-7"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/9781555818005.ch29"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/41483"},{"key":"e_1_3_3_38_2","unstructured":"European Committee on Antimicrobial Susceptibility Testing. 2022. Breakpoint tables for interpretation of MICs and zone diameters version 12.0. http:\/\/www.eucast.org."},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/48.suppl_1.17"},{"key":"e_1_3_3_40_2","volume-title":"StatPearls.","author":"Weir CB","year":"2021","unstructured":"Weir CB, Le JK. 2021. Metronidazole. In StatPearls. StatPearls Publishing, Treasure Island, FL."},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v2.i3.35"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201411296"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14433"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.9.3672-3679.1997"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1517\/03009734000000045"},{"key":"e_1_3_3_46_2","first-page":"291","article-title":"Coccoid formation as a mechanism of species-preservation in Helicobacter pylori: an ultrastructural study","volume":"83","author":"Saito N","year":"2008","unstructured":"Saito N, Konishi K, Kato M, Takeda H, Asaka M, Ooi HK. 2008. Coccoid formation as a mechanism of species-preservation in Helicobacter pylori: an ultrastructural study. Hokkaido Igaku Zasshi 83:291\u2013295.","journal-title":"Hokkaido Igaku Zasshi"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00095-18"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00963-09"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/274096"},{"key":"e_1_3_3_50_2","first-page":"62","article-title":"Effect of different stress conditions on antibiotic susceptibility of coagulase positive thermo tolerant Staphylococcus aureus","volume":"8","author":"Kumar R","year":"2020","unstructured":"Kumar R, Savalia C. 2020. Effect of different stress conditions on antibiotic susceptibility of coagulase positive thermo tolerant Staphylococcus aureus. Octa J Biosci 8:62\u201372.","journal-title":"Octa J Biosci"},{"key":"e_1_3_3_51_2","first-page":"328","article-title":"Effects of salt stress on the antimicrobial drug resistance and protein profile of Staphylococcus aureus","volume":"5","author":"Ganjian H","year":"2012","unstructured":"Ganjian H, Nikokar I, Tieshayar A, Mostafaei A, Amirmozafari N, Kiani S. 2012. Effects of salt stress on the antimicrobial drug resistance and protein profile of Staphylococcus aureus. Jundishapur J Microbiol 5:328\u2013331.","journal-title":"Jundishapur J Microbiol"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.7.3009-3010.2005"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00957-18"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2014.0019"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01297-17"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10069"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00035-10"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.95.3.775-781.1968"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.51998"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402591111"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.159.3.919-924.1984"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2006.02.006"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.5662\/wjm.v5.i3.164"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00188-11"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2013.7.6.655"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.02.015"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.7.2169-2178.2003"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2006.00398.x"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.024617"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2012.43"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2019.04.040"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nfs.2015.03.001"},{"key":"e_1_3_3_73_2","unstructured":"Kyoto Encyclopedia of Genes and Genomes. 2021. Starch and sucrose metabolism\u2014 Helicobacter pylori G27. https:\/\/www.genome.jp\/kegg-bin\/show_pathway?hpg00500. Accessed 26 October 2021."},{"key":"e_1_3_3_74_2","unstructured":"Kyoto Encyclopedia of Genes and Genomes. 2021. Two-component system\u2014 Helicobacter pylori G27. https:\/\/www.genome.jp\/kegg-bin\/show_pathway?hpg02020. Accessed 26 October 2021."},{"key":"e_1_3_3_75_2","unstructured":"Kyoto Encyclopedia of Genes and Genomes. 2021. ABC transporters\u2014 Helicobacter pylori G27. https:\/\/www.genome.jp\/kegg-bin\/show_pathway?hpg02010. Accessed 26 October 2021."},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01409-12"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-019-04387-4"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.12.5791"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01416-08"}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jb.00045-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jb.00045-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T13:04:34Z","timestamp":1652792674000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jb.00045-22"}},"subtitle":[],"editor":[{"given":"George","family":"O\u2019Toole","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,5,17]]},"references-count":78,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5,17]]}},"alternative-id":["10.1128\/jb.00045-22"],"URL":"https:\/\/doi.org\/10.1128\/jb.00045-22","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,17]]},"assertion":[{"value":"2022-02-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00045-22"}}