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In\n            <jats:italic>Shigella<\/jats:italic>\n            species, plasmid-borne virulence genes, such as those encoding the type III secretion system (T3SS), are silenced by the histone-like nucleoid structuring protein H-NS and antisilenced by VirB. Previous work at the plasmid-borne\n            <jats:italic>icsP<\/jats:italic>\n            locus revealed that VirB binds to a remotely located\n            <jats:italic>cis<\/jats:italic>\n            -acting regulatory site to relieve transcriptional silencing mediated by H-NS. Here, we characterize a second example of remote VirB antisilencing at\n            <jats:italic>ospD1<\/jats:italic>\n            , which encodes a T3SS antiactivator and effector. Our study highlights that remote transcriptional silencing and antisilencing occur more frequently in\n            <jats:italic>Shigella<\/jats:italic>\n            than previously thought, and it raises the possibility that long-range transcriptional regulation in bacteria is commonplace.\n          <\/jats:p>","DOI":"10.1128\/jb.00072-20","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T12:01:19Z","timestamp":1582804879000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["The Antiactivator of Type III Secretion, OspD1, Is Transcriptionally Regulated by VirB and H-NS from Remote Sequences in Shigella flexneri"],"prefix":"10.1128","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-6511","authenticated-orcid":false,"given":"Joy A.","family":"McKenna","sequence":"first","affiliation":[{"name":"School of Life Sciences, University of Nevada Las Vegas, 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