{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:58:59Z","timestamp":1790488739558,"version":"4.1.0"},"reference-count":63,"publisher":"American Society for Microbiology","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Bacteriology"],"published-print":{"date-parts":[[2012,5,15]]},"DOI":"10.1128\/jb.00090-12","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T09:50:32Z","timestamp":1330941032000},"page":"2426-2436","source":"Crossref","is-referenced-by-count":73,"title":["Characterization of the Response to Zinc Deficiency in the Cyanobacterium Anabaena sp. Strain PCC 7120"],"prefix":"10.1128","volume":"194","author":[{"given":"M.","family":"Napolitano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Santamaria-Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Olmedo-Verd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. J.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Luque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","published-online":{"date-parts":[[2012,3,2]]},"reference":[{"key":"key20180919080943_B1","volume-title":"Current protocols in molecular biology","author":"Ausubel","year":"2010"},{"key":"key20180919080943_B2","doi-asserted-by":"crossref","first-page":"5826","DOI":"10.1128\/JB.184.21.5826-5832.2002","article-title":"Recognition of DNA by Fur: a reinterpretation of the Fur box consensus sequence","volume":"184","author":"Baichoo","year":"2002","journal-title":"J. Bacteriol."},{"key":"key20180919080943_B3","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1046\/j.1365-2958.2002.03113.x","article-title":"Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon","volume":"45","author":"Baichoo","year":"2002","journal-title":"Mol. Microbiol."},{"key":"key20180919080943_B4","doi-asserted-by":"crossref","first-page":"7794","DOI":"10.1073\/pnas.93.15.7794","article-title":"Sensitive detection of bacterial transcription initiation sites and differentiation from RNA processing sites in the pheromone-induced plasmid transfer system of Enterococcus faecalis","volume":"93","author":"Bensing","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"key20180919080943_B5","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/j.1365-2958.2010.07475.x","article-title":"Role of a Zn-independent DksA in Zn homeostasis and stringent response","volume":"79","author":"Blaby-Haas","year":"2011","journal-title":"Mol. Microbiol."},{"key":"key20180919080943_B6","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.poly.2005.08.019","article-title":"Metal complexes of N,N,N\u2032,N\u2032-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN): variable coordination numbers and geometries","volume":"25","author":"Blindauer","year":"2006","journal-title":"Polyhedron"},{"key":"key20180919080943_B7","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1002\/cbdv.200890183","article-title":"Zinc-handling in cyanobacteria: an update","volume":"5","author":"Blindauer","year":"2008","journal-title":"Chem. Biodivers."},{"key":"key20180919080943_B8","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1046\/j.1365-2958.2002.03109.x","article-title":"Multiple bacteria encode metallothioneins and SmtA-like zinc fingers","volume":"45","author":"Blindauer","year":"2002","journal-title":"Mol. Microbiol."},{"key":"key20180919080943_B9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1365-2958.2004.04106.x","article-title":"Chimeras of P-type ATPases and their transcriptional regulators: contributions of a cytosolic amino-terminal domain to metal specificity","volume":"53","author":"Borrelly","year":"2004","journal-title":"Mol. Microbiol."},{"key":"key20180919080943_B10","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1046\/j.1365-2958.1999.01229.x","article-title":"ZntR is a Zn(II)-responsive MerR-like transcriptional regulator of zntA in Escherichia coli","volume":"31","author":"Brocklehurst","year":"1999","journal-title":"Mol. Microbiol."},{"key":"key20180919080943_B11","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1126\/science.276.5316.1221","article-title":"Trichodesmium, a globally significant marine cyanobacterium","volume":"276","author":"Capone","year":"1997","journal-title":"Science"},{"key":"key20180919080943_B12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0168-6445(03)00050-0","article-title":"Zn, Cu and Co in cyanobacteria: selective control of metal availability","volume":"27","author":"Cavet","year":"2003","journal-title":"FEMS Microbiol. Rev."},{"key":"key20180919080943_B13","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1146\/annurev.bi.61.070192.004341","article-title":"Zinc proteins: enzymes, storage proteins, transcription factors, and replication proteins","volume":"61","author":"Coleman","year":"1992","journal-title":"Annu. Rev. Biochem."},{"key":"key20180919080943_B14","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0076-6879(88)67086-8","article-title":"Conjugal transfer of DNA to cyanobacteria","volume":"167","author":"Elhai","year":"1988","journal-title":"Methods Enzymol."},{"key":"key20180919080943_B15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0378-1119(88)90605-1","article-title":"A versatile class of positive-selection vectors based on the nonviability of palindrome-containing plasmids that allows cloning into long polylinkers","volume":"68","author":"Elhai","year":"1988","journal-title":"Gene"},{"key":"key20180919080943_B16","doi-asserted-by":"crossref","first-page":"37586","DOI":"10.1074\/jbc.M607114200","article-title":"Discovery of a new prokaryotic type I GTP cyclohydrolase family","volume":"281","author":"El Yacoubi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"key20180919080943_B17","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.1128\/JB.181.20.6223-6229.1999","article-title":"Opening the iron box: transcriptional metalloregulation by the Fur protein","volume":"181","author":"Escolar","year":"1999","journal-title":"J. Bacteriol."},{"key":"key20180919080943_B18","doi-asserted-by":"crossref","first-page":"7567","DOI":"10.1128\/JB.01532-07","article-title":"Functional definition and global regulation of Zur, a zinc uptake regulator in a Streptococcus suis serotype 2 strain causing streptococcal toxic shock syndrome","volume":"190","author":"Feng","year":"2008","journal-title":"J. Bacteriol."},{"key":"key20180919080943_B19","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1128\/JB.180.22.5815-5821.1998","article-title":"Identification of a zinc-specific metalloregulatory protein, Zur, controlling zinc transport operons in Bacillus subtilis","volume":"180","author":"Gaballa","year":"1998","journal-title":"J. Bacteriol."},{"key":"key20180919080943_B20","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1128\/JB.184.23.6508-6514.2002","article-title":"Functional analysis of the Bacillus subtilis Zur regulon","volume":"184","author":"Gaballa","year":"2002","journal-title":"J. Bacteriol."},{"key":"key20180919080943_B21","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.1128\/JB.00802-09","article-title":"Contributions of Zur-controlled ribosomal proteins to growth under zinc starvation conditions","volume":"191","author":"Gabriel","year":"2009","journal-title":"J. Bacteriol."},{"key":"key20180919080943_B22","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1128\/JB.01978-07","article-title":"Regulation of the Bacillus subtilis yciC gene and insights into the DNA-binding specificity of the zinc-sensing metalloregulator Zur","volume":"190","author":"Gabriel","year":"2008","journal-title":"J. Bacteriol."},{"key":"key20180919080943_B23","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1016\/0967-0637(93)90104-B","article-title":"The marine prochlorophyte Prochlorococcus contributes significantly to phytoplankton biomass and primary production in the Sargasso Sea","volume":"40","author":"Goericke","year":"1993","journal-title":"Deep Sea Res."},{"key":"key20180919080943_B24","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1186\/1471-2164-10-470","article-title":"A subset of the diverse COG0523 family of putative metal chaperones is linked to zinc homeostasis in all kingdoms of life","volume":"10","author":"Haas","year":"2009","journal-title":"BMC Genomics"},{"key":"key20180919080943_B25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1741-7007-4-29","article-title":"Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM\/EpsH system. Application of a novel phylogenetic profiling heuristic","volume":"4","author":"Haft","year":"2006","journal-title":"BMC Biol."},{"key":"key20180919080943_B26","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.mib.2005.02.001","article-title":"Bacterial zinc uptake and regulators","volume":"8","author":"Hantke","year":"2005","journal-title":"Curr. Opin. Microbiol."},{"key":"key20180919080943_B27","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1574-6968.2004.tb09658.x","article-title":"Three fur homologues from Anabaena sp. PCC7120: exploring reciprocal protein-promoter recognition","volume":"236","author":"Hern\u00e1ndez","year":"2004","journal-title":"FEMS Microbiol. Lett."},{"key":"key20180919080943_B28","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0923-2508(01)01193-7","article-title":"ABC transporters: physiology, structure and mechanism\u2013an overview","volume":"152","author":"Higgins","year":"2001","journal-title":"Res. Microbiol."},{"key":"key20180919080943_B29","doi-asserted-by":"crossref","first-page":"15390","DOI":"10.1073\/pnas.1110137108","article-title":"Bacterial outer membrane channel for divalent metal ion acquisition","volume":"108","author":"Hohle","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"key20180919080943_B30","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1128\/AEM.02481-08","article-title":"Bioinformatic and expression analyses of genes mediating zinc homeostasis in Nostoc punctiforme","volume":"75","author":"Hudek","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"key20180919080943_B31","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1074-5521(02)00296-X","article-title":"An unusual phylogenetic variation in the metal ion binding sites of porphobilinogen synthase","volume":"10","author":"Jaffe","year":"2003","journal-title":"Chem. Biol."},{"key":"key20180919080943_B32","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1365-2958.2007.05849.x","article-title":"The novel transcriptional regulator SczA mediates protection against Zn2+ stress by activation of the Zn2+-resistance gene czcD in Streptococcus pneumoniae","volume":"65","author":"Kloosterman","year":"2007","journal-title":"Mol. Microbiol."},{"key":"key20180919080943_B33","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s10534-006-9070-7","article-title":"Functional specialization within the Fur family of metalloregulators","volume":"20","author":"Lee","year":"2007","journal-title":"Biometals"},{"key":"key20180919080943_B34","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2180-9-128","article-title":"Characterization of Zur-dependent genes and direct Zur targets in Yersinia pestis","volume":"9","author":"Li","year":"2009","journal-title":"BMC Microbiol."},{"key":"key20180919080943_B35","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3354\/ame012039","article-title":"Prochlorococcus growth rate and contribution to primary production in the equatorial and subtropical North Pacific Ocean","volume":"12","author":"Liu","year":"1997","journal-title":"Aquatic Microb. Ecol."},{"key":"key20180919080943_B36","doi-asserted-by":"crossref","first-page":"8673","DOI":"10.1021\/bi050450+","article-title":"A zinc(II)\/lead(II)\/cadmium(II)-inducible operon from the cyanobacterium Anabaena is regulated by AztR, an alpha3N ArsR\/SmtB metalloregulator","volume":"44","author":"Liu","year":"2005","journal-title":"Biochemistry"},{"key":"key20180919080943_B37","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1128\/JB.01109-10","article-title":"Lactococcus lactis ZitR is a zinc-responsive repressor active in the presence of low, nontoxic zinc concentrations in vivo","volume":"193","author":"Llull","year":"2011","journal-title":"J. Bacteriol."},{"key":"key20180919080943_B38","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1042\/BJ20081066","article-title":"New insights into the role of Fur proteins: FurB (All2473) from Anabaena protects DNA and increases cell survival under oxidative stress","volume":"418","author":"L\u00f3pez-Gomoll\u00f3n","year":"2009","journal-title":"Biochem. J."},{"key":"key20180919080943_B39","doi-asserted-by":"crossref","first-page":"9914","DOI":"10.1074\/jbc.M609974200","article-title":"Crystal structure and function of the zinc uptake regulator FurB from Mycobacterium tuberculosis","volume":"282","author":"Lucarelli","year":"2007","journal-title":"J. Biol. Chem."},{"key":"key20180919080943_B40","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1046\/j.1365-2958.2002.03236.x","article-title":"Expression of the glutamyl-tRNA synthetase gene from the cyanobacterium Synechococcus sp PCC 7942 depends on nitrogen availability and the global regulator NtcA","volume":"46","author":"Luque","year":"2002","journal-title":"Mol. Microbiol."},{"key":"key20180919080943_B41","doi-asserted-by":"crossref","first-page":"9130","DOI":"10.1093\/nar\/gkr625","article-title":"Sequential binding and sensing of Zn(II) by Bacillus subtilis Zur","volume":"39","author":"Ma","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"key20180919080943_B42","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1128\/JB.01190-06","article-title":"Global analysis of the Mycobacterium tuberculosis Zur (FurB) regulon","volume":"189","author":"Maciag","year":"2007","journal-title":"J. Bacteriol."},{"key":"key20180919080943_B43","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1741-7007-7-68","article-title":"TonB-dependent transporters and their occurrence in cyanobacteria","volume":"7","author":"Mirus","year":"2009","journal-title":"BMC Biol."},{"key":"key20180919080943_B44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1146\/annurev.micro.112408.134247","article-title":"TonB-dependent transporters: regulation, structure, and function","volume":"64","author":"Noinaj","year":"2010","journal-title":"Annu. Rev. Microbiol."},{"key":"key20180919080943_B45","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1126\/science.1060331","article-title":"Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis","volume":"292","author":"Outten","year":"2001","journal-title":"Science"},{"key":"key20180919080943_B46","doi-asserted-by":"crossref","first-page":"9912","DOI":"10.1073\/pnas.1733691100","article-title":"Comparative genomics of bacterial zinc regulons: enhanced ion transport, pathogenesis, and rearrangement of ribosomal proteins","volume":"100","author":"Panina","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"key20180919080943_B47","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1128\/MMBR.63.1.106-127.1999","article-title":"Prochlorococcus, a marine photosynthetic prokaryote of global significance","volume":"63","author":"Partensky","year":"1999","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"key20180919080943_B48","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0076-6879(88)67004-2","article-title":"Isolation and purification of cyanobacteria","volume":"167","author":"Rippka","year":"1988","journal-title":"Methods Enzymol."},{"key":"key20180919080943_B49","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1098\/rspb.1990.0130","article-title":"Prokaryotic metallothionein gene characterization and expression: chromosome crawling by ligation-mediated PCR","volume":"242","author":"Robinson","year":"1990","journal-title":"Proc. Biol. Sci."},{"key":"key20180919080943_B50","doi-asserted-by":"crossref","first-page":"6936","DOI":"10.1128\/JB.00287-09","article-title":"Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB","volume":"191","author":"Sankaran","year":"2009","journal-title":"J. Bacteriol."},{"key":"key20180919080943_B51","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/j.1365-2958.2006.05578.x","article-title":"Novel nickel transport mechanism across the bacterial outer membrane energized by the TonB\/ExbB\/ExbD machinery","volume":"63","author":"Schauer","year":"2007","journal-title":"Mol. Microbiol."},{"key":"key20180919080943_B52","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2164-11-12","article-title":"The Zur regulon of Corynebacterium glutamicum ATCC 13032","volume":"11","author":"Schroder","year":"2010","journal-title":"BMC Genomics"},{"key":"key20180919080943_B53","volume-title":"Biochemical calculations","author":"Segel","year":"1976","edition":"2nd ed"},{"key":"key20180919080943_B54","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1039\/c1mt00030f","article-title":"Transcriptional response of Streptococcus pneumoniae to Zn2+ limitation and the repressor\/activator function of AdcR","volume":"3","author":"Shafeeq","year":"2011","journal-title":"Metallomics"},{"key":"key20180919080943_B55","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1073\/pnas.1017744108","article-title":"Graded expression of zinc-responsive genes through two regulatory zinc-binding sites in Zur","volume":"108","author":"Shin","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"key20180919080943_B56","doi-asserted-by":"crossref","first-page":"6709","DOI":"10.1128\/JB.00680-06","article-title":"Transcriptional response of Escherichia coli to TPEN","volume":"188","author":"Sigdel","year":"2006","journal-title":"J. Bacteriol."},{"key":"key20180919080943_B57","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1574-6976.2000.tb00546.x","article-title":"Prokaryotic carbonic anhydrases","volume":"24","author":"Smith","year":"2000","journal-title":"FEMS Microbiol. Rev."},{"key":"key20180919080943_B58","doi-asserted-by":"crossref","first-page":"e1000969","DOI":"10.1371\/journal.ppat.1000969","article-title":"An outer membrane receptor of Neisseria meningitidis involved in zinc acquisition with vaccine potential","volume":"6","author":"Stork","year":"2010","journal-title":"PLoS Pathog."},{"key":"key20180919080943_B59","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1073\/pnas.1117515109","article-title":"Cyanobacterial metallochaperone inhibits deleterious side reactions of copper","volume":"109","author":"Tottey","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"key20180919080943_B60","doi-asserted-by":"crossref","first-page":"6331","DOI":"10.1093\/nar\/20.23.6331","article-title":"Analysis of the gene encoding the RNA subunit of ribonuclease P from cyanobacteria","volume":"20","author":"Vioque","year":"1992","journal-title":"Nucleic Acids Res."},{"key":"key20180919080943_B61","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrmicro2057","article-title":"How do bacterial cells ensure that metalloproteins get the correct metal?","volume":"7","author":"Waldron","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"key20180919080943_B62","first-page":"1","article-title":"Introduction to the cyanobacteria","author":"Whitton","year":"2002","journal-title":"The ecology of cyanobacteria: their diversity in time and space"},{"key":"key20180919080943_B63","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1093\/bioinformatics\/btq249","article-title":"PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes","volume":"26","author":"Yu","year":"2010","journal-title":"Bioinformatics"}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1128\/JB.00090-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T13:23:46Z","timestamp":1627565026000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JB.00090-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,2]]},"references-count":63,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2012,4,24]]},"published-print":{"date-parts":[[2012,5,15]]}},"URL":"https:\/\/doi.org\/10.1128\/jb.00090-12","relation":{},"ISSN":["0021-9193"],"issn-type":[{"value":"0021-9193","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3,2]]}}}