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These sequences are frequently monitored as biocide resistance markers in antimicrobial resistance surveillance studies. Our findings reveal that enterobacterial\n            <jats:italic>gdm<\/jats:italic>\n            sequences transmitted on plasmids possess a guanidine II riboswitch, which restricts transcript translation in the presence of guanidinium. Cloning and overexpression of this\n            <jats:italic>gdm<\/jats:italic>\n            sequence revealed that it confers higher resistance to quaternary ammonium compound (QAC) disinfectants (which possess guanidium moieties) when grown as biofilms. Since biofilms are commonly eradicated with QAC-containing compounds, the presence of this gene on plasmids and its biofilm-specific resistance are a growing concern for clinical and food safety prevention measures.\n          <\/jats:p>","DOI":"10.1128\/jb.00104-20","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T14:17:58Z","timestamp":1599833878000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Riboswitch-Associated Guanidinium-Selective Efflux Pumps Frequently Transmitted on Proteobacterial Plasmids Increase Escherichia coli Biofilm Tolerance to Disinfectants"],"prefix":"10.1128","volume":"202","author":[{"given":"Carmine J.","family":"Slipski","sequence":"first","affiliation":[{"name":"University of Manitoba, Medical Microbiology and Infectious Disease, Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7234-1395","authenticated-orcid":false,"given":"Taylor R.","family":"Jamieson","sequence":"additional","affiliation":[{"name":"University of Manitoba, Medical Microbiology and Infectious Disease, Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George G.","family":"Zhanel","sequence":"additional","affiliation":[{"name":"University of Manitoba, Medical Microbiology and Infectious Disease, Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3620-828X","authenticated-orcid":false,"given":"Denice C.","family":"Bay","sequence":"additional","affiliation":[{"name":"University of Manitoba, Medical Microbiology and Infectious Disease, Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-017-9992-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-9-140"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-39658-3_3"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2007.08.015"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1719187115"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1482"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.184.9.2543-2545.2002"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2011.05.005"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2005.02664.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/1541-4337.12378"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00824"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.17221\/6013-VETMED"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00786-09"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116927"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.061804.117"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b01271"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b01270"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00069-19"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2015.03.018"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1039\/c5np00108k"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm981108g"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1546.2012.00277.x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0809.020063"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902400106"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01687-06"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2005.01.013"},{"key":"e_1_3_3_28_2","first-page":"15","article-title":"Efficacy of quaternary ammonium compounds on different conveyor chips contaminated with poultry rinsate","volume":"14","author":"Veluz GA","year":"2014","unstructured":"Veluz GA, Pitchiah S, Brashears MM, Alvarado CZ. 2014. 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