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Bacteriophage PA6 is the first phage of<jats:italic>P. acnes<\/jats:italic>to be sequenced and demonstrates a high degree of similarity to many mycobacteriophages both morphologically and genetically. PA6 possesses an icosahedreal head and long noncontractile tail characteristic of the<jats:italic>Siphoviridae<\/jats:italic>. The overall genome organization of PA6 resembled that of the temperate mycobacteriophages, although the genome was much smaller, 29,739 bp (48 predicted genes), compared to, for example, 50,550 bp (86 predicted genes) for the Bxb1 genome. PA6 infected only<jats:italic>P. acnes<\/jats:italic>and produced clear plaques with turbid centers, but it lacked any obvious genes for lysogeny. The host range of PA6 was restricted to<jats:italic>P. acnes<\/jats:italic>, but the phage was able to infect and lyse all<jats:italic>P. acnes<\/jats:italic>isolates tested. Sequencing of the PA6 genome makes an important contribution to the study of phage evolution and propionibacterial genetics.<\/jats:p>","DOI":"10.1128\/jb.00106-07","type":"journal-article","created":{"date-parts":[[2007,3,31]],"date-time":"2007-03-31T00:48:58Z","timestamp":1175302138000},"page":"4161-4167","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["Genome Sequence and Analysis of a<i>Propionibacterium acnes<\/i>Bacteriophage"],"prefix":"10.1128","volume":"189","author":[{"given":"Mark D.","family":"Farrar","sequence":"first","affiliation":[{"name":"Skin Research Centre, Institute of Molecular &amp; Cellular Biology, Garstang Building, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen M.","family":"Howson","sequence":"additional","affiliation":[{"name":"Skin Research Centre, Institute of Molecular &amp; Cellular Biology, Garstang Building, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Bojar","sequence":"additional","affiliation":[{"name":"Skin Research Centre, Institute of Molecular &amp; Cellular Biology, Garstang Building, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"West","sequence":"additional","affiliation":[{"name":"Sarum Biosciences Ltd., 8 Centre One, Lysander Way, Old Sarum Park, Salisbury SP4 6BU, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Towler","sequence":"additional","affiliation":[{"name":"Skin Research Centre, Institute of Molecular &amp; Cellular Biology, Garstang Building, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Parry","sequence":"additional","affiliation":[{"name":"Skin Research Centre, Institute of Molecular &amp; Cellular Biology, Garstang Building, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharine","family":"Pelton","sequence":"additional","affiliation":[{"name":"Skin Research Centre, Institute of Molecular &amp; Cellular Biology, Garstang Building, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith T.","family":"Holland","sequence":"additional","affiliation":[{"name":"Skin Research Centre, Institute of Molecular &amp; Cellular Biology, Garstang Building, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0098-1354(93)85018-H","volume":"17","year":"1993","unstructured":"Borodovsky, M., and J. 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