{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:14:22Z","timestamp":1792091662834,"version":"4.4.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2011,5,15]],"date-time":"2011-05-15T00:00:00Z","timestamp":1305417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2011,5,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The asparaginyl-tRNA synthetase-like SlgZ and methyltransferase SlgM enzymes are involved in the biosynthesis of the tetramic acid streptolydigin in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Streptomyces lydicus<\/jats:named-content>\n            . Inactivation of\n            <jats:italic>slgZ<\/jats:italic>\n            led to a novel streptolydigin derivative. Overexpression of\n            <jats:italic>slgZ<\/jats:italic>\n            ,\n            <jats:italic>slgM<\/jats:italic>\n            , or both in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. lydicus<\/jats:named-content>\n            led to a considerable increase in streptolydigin production.\n          <\/jats:p>","DOI":"10.1128\/jb.00108-11","type":"journal-article","created":{"date-parts":[[2011,3,14]],"date-time":"2011-03-14T00:08:17Z","timestamp":1300061297000},"page":"2647-2651","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin in Streptomyces lydicus: Tailoring Modification of 3-Methyl-Aspartate"],"prefix":"10.1128","volume":"193","author":[{"given":"Dina H.","family":"Horna","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Funcional e Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Funcional e Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Olano","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Funcional e Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Palomino-Sch\u00e4tzlein","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioqu\u00edmica Estructural, Departamento de Biolog\u00eda Qu\u00edmica, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, 46012 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pineda-Lucena","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioqu\u00edmica Estructural, Departamento de Biolog\u00eda Qu\u00edmica, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, 46012 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo J.","family":"Carbajo","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioqu\u00edmica Estructural, Departamento de Biolog\u00eda Qu\u00edmica, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, 46012 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo F.","family":"Bra\u00f1a","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Funcional e Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Funcional e Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Salas","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Funcional e Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0378-4347(00)85133-6","article-title":"Rapid analysis of amino acids using pre-column derivatization","volume":"336","author":"Bidlingmeyer B. 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