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The<jats:italic>scs<\/jats:italic>locus, which codes for periplasmic thiol\/disulfide-oxidoreductase\/isomerase-like proteins, has been the focus of attention because it is necessary for copper resistance, oxidative stress responses, and virulence and because it is not present in nonpathogenic<jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>. Still, the conditions under which the<jats:italic>scs<\/jats:italic>locus is expressed and the roles of its individual components remain unknown. In this report, we examine the contribution of each Scs factor to survival under H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>and copper stress. We establish that the<jats:italic>scs<\/jats:italic>genes form a copper-activated operon controlled by the CpxR\/CpxA signal transduction system, and we provide evidence of its conserved gene arrangement and regulation in other bacterial pathogens.<\/jats:p>","DOI":"10.1128\/jb.00126-18","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T12:46:21Z","timestamp":1528202781000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":56,"title":["CpxR\/CpxA Controls<i>scsABCD<\/i>Transcription To Counteract Copper and Oxidative Stress in Salmonella enterica Serovar Typhimurium"],"prefix":"10.1128","volume":"200","author":[{"given":"Carolina","family":"L\u00f3pez","sequence":"first","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular de Rosario, Universidad Nacional de Rosario-CONICET, Rosario, Argentina"},{"name":"Departamento de Microbiolog\u00eda, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Universidad Nacional de Rosario, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana K.","family":"Checa","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular de Rosario, Universidad Nacional de Rosario-CONICET, Rosario, Argentina"},{"name":"Departamento de Microbiolog\u00eda, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Universidad Nacional de Rosario, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8925-7763","authenticated-orcid":false,"given":"Fernando C.","family":"Soncini","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular de Rosario, Universidad Nacional de Rosario-CONICET, Rosario, Argentina"},{"name":"Departamento de Microbiolog\u00eda, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Universidad Nacional de Rosario, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"1","volume-title":"Bacteria-metal interactions","author":"Pontel LB","year":"2015","unstructured":"Pontel LB, Checa SK, Soncini FC. 2015. 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