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The control of the T3SS has not been well studied in this obligate intracellular pathogen. Here, we show that Scc4 plays a major role for precise control of the pathogenic T3SS at the levels of gene expression and effector secretion through genetically separable protein networks, allowing a fast adaptive mode of\n            <jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>\n            development during infection in human epithelial cells.\n          <\/jats:p>","DOI":"10.1128\/jb.00132-20","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T13:59:17Z","timestamp":1589378357000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Context-Dependent Action of Scc4 Reinforces Control of the Type III Secretion System"],"prefix":"10.1128","volume":"202","author":[{"given":"Leiqiong","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanguang","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"},{"name":"Precision Medicine Center, Traditional Chinese Medicine Hospital affiliated with Southwest Medical University, Luzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory V.","family":"Plano","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiancai","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"},{"name":"Department of Microbiology, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndsey N.","family":"Gisclair","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Schesser Bartra","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan A.","family":"Macnaughtan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00917-13"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.20"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-092412-155725"},{"key":"e_1_3_3_5_2","volume-title":"Prevalence and incidence of selected sexually transmitted infections","author":"World Health Organization Department of Reproductive Health and Research","year":"2011","unstructured":"World Health Organization Department of Reproductive Health and Research. 2011. 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