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However, this perspective has resulted in the relative neglect of abundant yet poorly characterized members of the human microbiota. Few genera embody this oversight more clearly than\n                      <jats:italic toggle=\"yes\">Prevotella<\/jats:italic>\n                      . Despite being consistently found in high abundance across diverse human mucosal sites, including the oral cavity, airways, and vagina, the underlying physiological roles of the genus in both health and disease contexts remain largely unclear. This review traces the evolution of\n                      <jats:italic toggle=\"yes\">Prevotella<\/jats:italic>\n                      research and classification, arguing that the traditional \u201cfriend or foe\u201d dichotomy is insufficient. We contend that more mechanistic work at the species level is needed to elucidate the biology of\n                      <jats:italic toggle=\"yes\">Prevotella<\/jats:italic>\n                      , especially after the most recent taxonomic reclassification. The knowledge derived from a mechanistic focus will offer profound benefits for understanding and treating complex polymicrobial diseases across multiple systems, including chronic respiratory infections, oral inflammatory conditions, and recurrent genitourinary dysbiosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/jb.00133-26","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:13:12Z","timestamp":1783699992000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["The redefined identity of\n                    <i>Prevotella<\/i>\n                    : new implications for oral, respiratory, and vaginal health"],"prefix":"10.1128","volume":"208","author":[{"given":"Souzane","family":"Ntamubano","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00jmfr291","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular, Cellular, and Developmental Biology, University of Michigan","place":["Ann Arbor, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De'Jana","family":"Parker","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00jmfr291","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular, Cellular, and Developmental Biology, University of Michigan","place":["Ann Arbor, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2322-4085","authenticated-orcid":true,"given":"Ariangela J.","family":"Kozik","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00jmfr291","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular, Cellular, and Developmental Biology, University of Michigan","place":["Ann Arbor, USA"]},{"id":[{"id":"https:\/\/ror.org\/00jmfr291","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan","place":["Ann Arbor, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/28.4.341"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(62)90117-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02121285"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-1-2-109"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.80.2.164-170.1960"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-39-1-85"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00559-y"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.syapm.2022.126354"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-42-4-542"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1993.tb00309.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2009.11.003"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/anae.1997.0072"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/dsv032"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1350-6"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2010.08.008"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","unstructured":"Albright C Anil G Evans JT Ntamubano S Kozik AJ. 2026. 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