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In this study, we show that the Mla pathway, a system involved in maintaining the integrity of the outer membrane, is genetically and functionally different in\n            <jats:named-content content-type=\"genus-species\">Burkholderia cepacia<\/jats:named-content>\n            complex species compared to that in other proteobacteria. Mutants in\n            <jats:italic>mla<\/jats:italic>\n            genes of\n            <jats:named-content content-type=\"genus-species\">Burkholderia cenocepacia<\/jats:named-content>\n            or\n            <jats:named-content content-type=\"genus-species\">Burkholderia dolosa<\/jats:named-content>\n            were sensitive to Gram-positive antibiotics, while this effect was not observed in\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            or\n            <jats:named-content content-type=\"genus-species\">Pseudomonas aeruginosa<\/jats:named-content>\n            . The Mla pathway in\n            <jats:named-content content-type=\"genus-species\">Burkholderia<\/jats:named-content>\n            species may represent an ideal genus-specific target to address their intrinsic antimicrobial resistances.\n          <\/jats:p>","DOI":"10.1128\/jb.00156-18","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T10:42:23Z","timestamp":1531132943000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["The Mla Pathway Plays an Essential Role in the Intrinsic Resistance of Burkholderia cepacia Complex Species to Antimicrobials and Host Innate Components"],"prefix":"10.1128","volume":"200","author":[{"given":"Steve P.","family":"Bernier","sequence":"first","affiliation":[{"name":"Department of Medicine, Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susie","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Medicine, Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Surette","sequence":"additional","affiliation":[{"name":"Department of Medicine, Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada"},{"name":"Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.8221.1"},{"key":"e_1_3_3_3_2","volume-title":"Biosecurity and bioterrorism","author":"Ryan JR","year":"2016","unstructured":"Ryan JR. 2016. 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