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Key virulence genes in\n            <jats:named-content content-type=\"genus-species\">L. monocytogenes<\/jats:named-content>\n            are activated by the transcription regulator PrfA, a DNA binding protein belonging to the CRP\/FNR family. Various signals from the environment are known to affect the activity of PrfA, either positively or negatively. Recently, we found that specific medium- and long-chain free fatty acids act as antimicrobial agents as well as signaling compounds in\n            <jats:named-content content-type=\"genus-species\">L. monocytogenes<\/jats:named-content>\n            . Here, we show that both antimicrobial and nonantimicrobial free fatty acids inhibit PrfA-dependent activation of virulence gene transcription by interfering with the DNA binding activity of PrfA. Our findings suggest that free fatty acids could be candidates for alternative therapies against\n            <jats:named-content content-type=\"genus-species\">L. monocytogenes<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/jb.00156-20","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T13:25:20Z","timestamp":1594214720000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Free Fatty Acids Interfere with the DNA Binding Activity of the Virulence Regulator PrfA of Listeria monocytogenes"],"prefix":"10.1128","volume":"202","author":[{"given":"Patr\u00edcia T.","family":"dos Santos","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke S. 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