{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:46:37Z","timestamp":1790739997800,"version":"4.1.0"},"reference-count":71,"publisher":"American Society for Microbiology","issue":"20","license":[{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2019,10,15]]},"abstract":"<jats:p>\n            The type four pilus (Tfp) of\n            <jats:named-content content-type=\"genus-species\">Neisseria meningitidis<\/jats:named-content>\n            contributes to fundamental processes such as adhesion, transformation, and disease pathology. Meningococci express one of two distinct classes of Tfp (class I or class II), which can be distinguished antigenically or by the major subunit (\n            <jats:italic>pilE<\/jats:italic>\n            ) locus and its genetic context. The factors that govern transcription of the class II\n            <jats:italic>pilE<\/jats:italic>\n            gene are not known, even though it is present in isolates that cause epidemic disease. Here we show that the transcription of class II\n            <jats:italic>pilE<\/jats:italic>\n            is maintained throughout growth and under different stress conditions and is driven by a \u03c3\n            <jats:sup>70<\/jats:sup>\n            -dependent promoter. This is distinct from Tfp regulation in nonpathogenic\n            <jats:italic>Neisseria<\/jats:italic>\n            spp. and may confer an advantage during host-cell interaction and infection.\n          <\/jats:p>","DOI":"10.1128\/jb.00170-19","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T10:50:16Z","timestamp":1563879016000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Contribution of \u03c3\n            <sup>70<\/sup>\n            and \u03c3\n            <sup>N<\/sup>\n            Factors to Expression of Class II\n            <i>pilE<\/i>\n            in Neisseria meningitidis"],"prefix":"10.1128","volume":"201","author":[{"given":"Mariya","family":"Lobanovska","sequence":"first","affiliation":[{"name":"Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph M.","family":"Tang","sequence":"additional","affiliation":[{"name":"Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M.","family":"Exley","sequence":"additional","affiliation":[{"name":"Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2014.11.006"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12647"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.3140"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2807\/esm.10.12.00586-en"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1993.tb00972.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201488031"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000314"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1173196"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00099-10"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00935.x"},{"key":"e_1_3_3_12_2","first-page":"3239","article-title":"Identification of epitopes recognized by monoclonal antibodies SM1 and SM2 which react with all pili of Neisseria gonorrhoeae but which differentiate between two structural classes of pili expressed by Neisseria meningitidis and the distribution of their encoding sequences in the genomes of Neisseria spp","volume":"135","author":"Virji M","year":"1989","unstructured":"Virji M, Heckels JE, Potts WJ, Hart CA, Saunders JR. 1989. Identification of epitopes recognized by monoclonal antibodies SM1 and SM2 which react with all pili of Neisseria gonorrhoeae but which differentiate between two structural classes of pili expressed by Neisseria meningitidis and the distribution of their encoding sequences in the genomes of Neisseria spp. J Gen Microbiol 135:3239\u20133251.","journal-title":"J Gen Microbiol"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.7.2613-2620.1997"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-253"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175653"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1992.tb02001.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/315156a0"},{"key":"e_1_3_3_18_2","first-page":"1","article-title":"Molecular mechanisms of antigenic variation in Neisseria gonorrhoeae","volume":"1","author":"Seifert HS","year":"1992","unstructured":"Seifert HS. 1992. Molecular mechanisms of antigenic variation in Neisseria gonorrhoeae. 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