{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:39:00Z","timestamp":1792647540692,"version":"4.5.0"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"14","license":[{"start":{"date-parts":[[2010,7,15]],"date-time":"2010-07-15T00:00:00Z","timestamp":1279152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2010,7,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Cyclo(Phe-Pro) is a cyclic dipeptide produced by multiple\n            <jats:italic>Vibrio<\/jats:italic>\n            species. In this work, we present evidence that cyclo(Phe-Pro) inhibits the production of the virulence factors cholera toxin (CT) and toxin-coregulated pilus (TCP) in O1 El Tor\n            <jats:italic>Vibrio cholerae<\/jats:italic>\n            strain N16961 during growth under virulence gene-inducing conditions. The cyclo(Phe-Pro) inhibition of CT and TCP production correlated with reduced transcription of the virulence regulator\n            <jats:italic>tcpPH<\/jats:italic>\n            and was alleviated by overexpression of\n            <jats:italic>tcpPH<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/jb.00191-10","type":"journal-article","created":{"date-parts":[[2010,5,8]],"date-time":"2010-05-08T02:01:13Z","timestamp":1273284073000},"page":"3829-3832","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["The Cyclic Dipeptide Cyclo(Phe-Pro) Inhibits Cholera Toxin and Toxin-Coregulated Pilus Production in O1 El Tor\n            <i>Vibrio cholerae<\/i>"],"prefix":"10.1128","volume":"192","author":[{"given":"Xiaowen R.","family":"Bina","sequence":"first","affiliation":[{"name":"The University of Tennessee Health Sciences Center, Department of Molecular Sciences, 858 Madison Avenue, Memphis, Tennessee 38163"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Bina","sequence":"additional","affiliation":[{"name":"The University of Tennessee Health Sciences Center, Department of Molecular Sciences, 858 Madison Avenue, Memphis, Tennessee 38163"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.15.4669-4672.1999"},{"key":"e_1_3_1_3_2","first-page":"103","volume":"63","year":"2009","unstructured":"Bina, X. 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