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The underlying mechanisms all involve its reaction with iron atoms, whether in enzymes or on the surface of DNA. Accordingly, when bacteria perceive toxic H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , they activate defensive tactics that are focused on iron metabolism. In this study, we identify a conundrum: DNA is best protected by the removal of iron from the cytoplasm, but this action impairs the ability of the cell to reactivate its iron-dependent enzymes. The actions of the Clp proteins appear to hedge against the oversequestration of iron by the miniferritin Dps. This buffering effect is important, because\n                    <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n                    seeks not just to survive H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    but to grow in its presence.\n                  <\/jats:p>","DOI":"10.1128\/jb.00235-20","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T09:39:06Z","timestamp":1592991546000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["During Oxidative Stress the Clp Proteins of\n                    <i>Escherichia coli<\/i>\n                    Ensure that Iron Pools Remain Sufficient To Reactivate Oxidized Metalloenzymes"],"prefix":"10.1128","volume":"202","author":[{"given":"Ananya","family":"Sen","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Illinois, Urbana, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Illinois, Urbana, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5266-7403","authenticated-orcid":false,"given":"James A.","family":"Imlay","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Illinois, Urbana, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1163100"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3032"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.11.279.701"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)63504-5"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04256.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)61255-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)55001-8"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607646200"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)41538-4"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01573-14"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.330365"},{"key":"e_1_3_3_13_2","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1016\/S0021-9258(17)30446-5","article-title":"Permeation of the erythrocyte stroma by superoxide radical","volume":"253","author":"Lynch R","year":"1978","unstructured":"Lynch R, Fridovich I. 1978. 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