{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:51:31Z","timestamp":1784289091581,"version":"3.55.0"},"reference-count":71,"publisher":"American Society for Microbiology","issue":"24","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100010178","name":"IU | Indiana University Bloomington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010178","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2020,11,19]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">V. cholerae<\/jats:named-content>\n            deploys an arsenal of virulence factors as it attempts to traverse a protective mucus layer and reach the epithelial surface of the distal small intestine. The T6SS used to cull bacterial competition during infection is induced by mucus. We show that this activity may serve an additional purpose by further decreasing motility in the presence of mucin, thereby reducing the probability of speed-dependent, near-perpendicular directional changes. We posit that this encourages cells to maintain course rather than change direction, which may aid those attempting to reach and colonize the epithelial surface.\n          <\/jats:p>","DOI":"10.1128\/jb.00261-20","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T14:34:48Z","timestamp":1598970888000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Vibrio cholerae Type VI Activity Alters Motility Behavior in Mucin"],"prefix":"10.1128","volume":"202","author":[{"given":"Abby","family":"Frederick","sequence":"first","affiliation":[{"name":"Department of Biology, Indiana University Bloomington, Bloomington, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhsun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biology, Indiana University Bloomington, Bloomington, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Biology, Indiana University Bloomington, Bloomington, Indiana, USA"},{"name":"Division of Gastroenterology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5133-4463","authenticated-orcid":false,"given":"Dean A.","family":"Rowe-Magnus","sequence":"additional","affiliation":[{"name":"Department of Biology, Indiana University Bloomington, Bloomington, Indiana, USA"},{"name":"Department of Molecular and Cellular Biochemistry, Indiana University Bloomington, Bloomington, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004787"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.240929"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.35"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00378-11"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins7030919"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.12.003"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10846"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.11.001"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706532104"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01266-10"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11546-6"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260064"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2436\/20.1501.01.294"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01240-08"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004031"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2011.11.008"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2505"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.68.2.301-319.2004"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fux052"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsle.2004.08.039"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802241105"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004405"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111581598"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308052101"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/355182a0"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011953108"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nphys2676"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1602307113"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00029-12"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709765105"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2014.11.3479"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9776"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.14763"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00670-19"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.7.2669-2678.1994"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.03.092"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00541-08"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.184.6.1767-1771.2002"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02348.x"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-14-22"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201591163"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.05414-11"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2006.05.034"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-fluid-122414-034606"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.24.8403-8410.2005"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05623.x"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02210-16"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.12.006"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05510-11"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048320"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00351-16"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209791"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2538"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.8.3733-3739.1999"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftx126"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1119\/1.10903"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2009.09.044"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.01.042"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00791-17"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5913"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-018-0052-7"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00073-12"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00932-07"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/35020000"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1406478111"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2008.06.004"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00190-18"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2011.01640.x"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2016.03.017"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-391857-4.00009-4"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.00261-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.00261-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T17:58:06Z","timestamp":1627581486000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JB.00261-20"}},"subtitle":[],"editor":[{"given":"Laurie E.","family":"Comstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,11,19]]},"references-count":71,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2020,11,19]]}},"alternative-id":["10.1128\/JB.00261-20"],"URL":"https:\/\/doi.org\/10.1128\/jb.00261-20","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,19]]},"assertion":[{"value":"2020-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}