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NAC's synthesis is entirely dependent on phosphorylated NtrC from the two-component Ntr system and requires the unusual sigma factor \u03c354 for transcription of the\n            <jats:italic>nac<\/jats:italic>\n            gene. NAC activates the transcription of \u03c370-dependent genes whose products provide the cell with ammonia or glutamate. NAC represses genes whose products use ammonia and also represses its own transcription. In addition, NAC also subtly adjusts other cellular functions to keep pace with the supply of biosynthetically available nitrogen.\n          <\/jats:p>","DOI":"10.1128\/jb.00266-10","type":"journal-article","created":{"date-parts":[[2010,7,31]],"date-time":"2010-07-31T01:45:04Z","timestamp":1280540704000},"page":"4801-4811","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["A NAC for Regulating Metabolism: the Nitrogen Assimilation Control Protein (NAC) from\n            <i>Klebsiella pneumoniae<\/i>"],"prefix":"10.1128","volume":"192","author":[{"given":"Robert A.","family":"Bender","sequence":"first","affiliation":[{"name":"Department of Molecular, Cellular, and Developmental Biology, the University of Michigan, Ann Arbor, Michigan 48109"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1111\/j.1365-2958.1991.tb01965.x","volume":"5","year":"1991","unstructured":"Bender, R. 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