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Despite the proposed significance of the\n            <jats:sc>d<\/jats:sc>\n            -galactonate metabolic pathway in the interaction of enteric bacteria with their hosts, there are no details on its regulation even in\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            , which has been known to utilize\n            <jats:sc>d<\/jats:sc>\n            -galactonate since the 1970s. Here, using multiple methodologies, we identified the promoter, operator, and effector of DgoR, the transcriptional repressor of\n            <jats:sc>d<\/jats:sc>\n            -galactonate metabolism in\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            . We establish DgoR as a GntR family transcriptional regulator. Recently, a human urinary tract isolate of\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            introduced in the mouse gut was found to accumulate missense mutations in\n            <jats:italic>dgoR<\/jats:italic>\n            . Our results show these mutants to be DNA binding defective, hence emphasizing the role of the\n            <jats:sc>d<\/jats:sc>\n            -galactonate metabolic pathway in bacterial colonization of the mammalian gut.\n          <\/jats:p>","DOI":"10.1128\/jb.00281-18","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T13:12:23Z","timestamp":1542373943000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Molecular and Functional Insights into the Regulation of\n            <scp>d<\/scp>\n            -Galactonate Metabolism by the Transcriptional Regulator DgoR in\n            <i>Escherichia coli<\/i>"],"prefix":"10.1128","volume":"201","author":[{"given":"Bhupinder","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali, SAS Nagar, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garima","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali, SAS Nagar, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeladrita","family":"Kundu","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali, SAS Nagar, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Sangwan","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali, SAS Nagar, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shachikanta","family":"Nongthombam","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali, SAS Nagar, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9156-4543","authenticated-orcid":false,"given":"Rachna","family":"Chaba","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali, SAS Nagar, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/ecosalplus.3.4.2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.9.3504-3511.1996"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.14.3495-3502.1998"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.MBP-0006-2014"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00413140"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.2.582-587.2002"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18597"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(58)90257-9"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.22.7690-7696.2004"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000297"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.02115.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(77)80234-2"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00415730"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1991.tb04544.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110968200"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1401"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.01089-15"},{"key":"e_1_3_3_19_2","first-page":"445","article-title":"Gluconobacter oxydans: its biotechnological applications","volume":"3","author":"Gupta A","year":"2001","unstructured":"Gupta A, Singh VK, Qazi GN, Kumar A. 2001. 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