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Species of\n            <jats:named-content content-type=\"genus-species\">Rickettsia<\/jats:named-content>\n            directly engage both extracellular and intracellular immunosurveillance, yet little is known about rickettsial lipid A. Here, we demonstrate that the alternative lipid A acyltransferase, LpxJ, from\n            <jats:named-content content-type=\"genus-species\">Rickettsia typhi<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">R. rickettsii<\/jats:named-content>\n            catalyzes the addition of C\n            <jats:sub>16<\/jats:sub>\n            fatty acid chains into the lipid A 3\u2032-linked primary acyl chain, accounting for major structural differences relative to the highly inflammatory lipid A of\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/jb.00334-18","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T10:33:49Z","timestamp":1531478029000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Rickettsia Lipid A Biosynthesis Utilizes the Late Acyltransferase LpxJ for Secondary Fatty Acid Addition"],"prefix":"10.1128","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1826-8879","authenticated-orcid":false,"given":"Mark L.","family":"Guillotte","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney E.","family":"Chandler","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Sayeedur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5016-8694","authenticated-orcid":false,"given":"Robert K.","family":"Ernst","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdu F.","family":"Azad","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"84","volume-title":"Intracellular pathogens II: rickettsiales","author":"Gillespie JJ","year":"2012","unstructured":"Gillespie JJ, Nordberg EK, Azad AF, Sobral BWS. 2012. Phylogeny and comparative genomics: the shifting landscape in the genomics era, p 84\u2013141. In Palmer GH, Azad AF (ed), Intracellular pathogens II: rickettsiales. 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