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In\n                      <jats:italic toggle=\"yes\">Bacillus subtilis<\/jats:italic>\n                      , SMC is required for the segregation of newly replicated origins. To investigate whether other proteins function with SMC in this process, we performed a synthetic lethal screen with an\n                      <jats:italic toggle=\"yes\">smc<\/jats:italic>\n                      hypomorphic allele (\n                      <jats:italic toggle=\"yes\">smc<\/jats:italic>\n                      *) that is mildly defective in chromosome segregation. In addition to recovering previously reported genetic interactions of\n                      <jats:italic toggle=\"yes\">smc<\/jats:italic>\n                      with\n                      <jats:italic toggle=\"yes\">parB<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">spoIIIE<\/jats:italic>\n                      , our screen identified\n                      <jats:italic toggle=\"yes\">minJ<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">divIVA<\/jats:italic>\n                      as essential in the\n                      <jats:italic toggle=\"yes\">smc*<\/jats:italic>\n                      background. We show that the synthetic lethality between\n                      <jats:italic toggle=\"yes\">smc*<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">\u2206minJ<\/jats:italic>\n                      or\n                      <jats:italic toggle=\"yes\">\u2206divIVA<\/jats:italic>\n                      arises from defects in segregating the replication terminus. Importantly, deletion of\n                      <jats:italic toggle=\"yes\">minD<\/jats:italic>\n                      , which suppresses the cell division defects of\n                      <jats:italic toggle=\"yes\">\u2206minJ<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">\u2206divIVA<\/jats:italic>\n                      , restored terminus segregation and viability in the\n                      <jats:italic toggle=\"yes\">smc*<\/jats:italic>\n                      background. These findings support a model in which proper septum formation promotes chromosome terminus resolution and segregation by enabling SpoIIIE-mediated DNA clearance from the division septum during cytokinesis. These findings highlight the interdependence between chromosome segregation and cell division.\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        The SMC complex plays a central role in chromosome organization and segregation in\n                        <jats:italic toggle=\"yes\">Bacillus subtilis<\/jats:italic>\n                        , but the cellular functions that become important when SMC activity is reduced are not well understood. Using a hypomorphic\n                        <jats:italic toggle=\"yes\">smc<\/jats:italic>\n                        allele, we discovered that mutations affecting cell division become essential when chromosome organization and segregation are impaired. Our findings support a model in which efficient septum formation enables proper localization of the SpoIIIE DNA translocase, which in turn resolves and segregates the chromosome terminus region. These results highlight the critical role of cell division in supporting chromosome segregation.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/jb.00345-26","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:28:55Z","timestamp":1791296935000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Efficient septum formation is essential for chromosome segregation in\n                    <i>Bacillus subtilis<\/i>\n                    when SMC function is impaired"],"prefix":"10.1128","author":[{"given":"Ngoc Khanh","family":"Lai","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01kg8sb98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biology, Indiana University","place":["Bloomington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura 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