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Thus, cytochrome\n            <jats:italic>bd<\/jats:italic>\n            complex assembly and activity are considered potential therapeutic targets. Here we report that the small protein CydX is required for the assembly and function of the cytochrome\n            <jats:italic>bd<\/jats:italic>\n            complex in\n            <jats:italic>S<\/jats:italic>\n            . Typhimurium under stress conditions, including exposure to \u03b2-mercaptoethanol, nitric oxide, or the phagocytic intracellular environment, demonstrating its crucial function for\n            <jats:italic>Salmonella<\/jats:italic>\n            fitness. However, cytochrome\n            <jats:italic>bd<\/jats:italic>\n            inactivation also leads to increased resistance to some antibiotics, so considerable caution should be taken when developing therapeutic strategies targeting the CydX-dependent cytochrome\n            <jats:italic>bd<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/jb.00348-19","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T11:20:22Z","timestamp":1572348022000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["The Small Protein CydX Is Required for Cytochrome\n            <i>bd<\/i>\n            Quinol Oxidase Stability and Function in Salmonella enterica Serovar Typhimurium: a Phenotypic Study"],"prefix":"10.1128","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0269-8257","authenticated-orcid":false,"given":"Kieu Minh","family":"Duc","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Chosun University School of Dentistry, Gwangju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Gyeong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Chosun University School of Dentistry, Gwangju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choa","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Chosun University School of Dentistry, Gwangju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jeong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Chosun University School of Dentistry, Gwangju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Mee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Chosun University School of Dentistry, Gwangju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hee","family":"Joung","sequence":"additional","affiliation":[{"name":"School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iel Soo","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Chosun University School of Dentistry, Gwangju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/ecosalplus.ESP-0012-2015"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ampbs.2017.05.002"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2011.06.016"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2014.10.006"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2014.01.016"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02052-16"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143808"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00324-13"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00872-09"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2012.00047"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2014.10.005"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.03.036"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf2477"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12318"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.03.004"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708845200"},{"key":"e_1_3_3_18_2","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1016\/S0021-9258(17)43304-7","article-title":"Terminal oxidases of Escherichia coli aerobic respiratory chain. 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