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However, transmission of\n                    <jats:named-content content-type=\"genus-species\">S. agalactiae<\/jats:named-content>\n                    from mother to newborn during vaginal birth is a leading cause of neonatal meningitis. Although colonized mothers who are at risk for transmission to the newborn are treated with antibiotics prior to delivery,\n                    <jats:named-content content-type=\"genus-species\">S. agalactiae<\/jats:named-content>\n                    is becoming increasingly resistant to current antibiotic therapies, and new treatments are needed. This research reveals a critical stress resistance pathway, glutathione synthesis, that is utilized by\n                    <jats:named-content content-type=\"genus-species\">S. agalactiae<\/jats:named-content>\n                    and contributes to its pathogenesis. Understanding the role of this unique bifunctional glutathione synthesis enzyme in\n                    <jats:named-content content-type=\"genus-species\">S. agalactiae<\/jats:named-content>\n                    during sepsis may help elucidate why\n                    <jats:named-content content-type=\"genus-species\">S. agalactiae<\/jats:named-content>\n                    produces such an abundance of glutathione compared to other bacteria.\n                  <\/jats:p>","DOI":"10.1128\/jb.00367-19","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T09:10:48Z","timestamp":1563786648000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Glutathione Synthesis Contributes to Virulence of\n                    <i>Streptococcus agalactiae<\/i>\n                    in a Murine Model of Sepsis"],"prefix":"10.1128","volume":"201","author":[{"given":"Elizabeth A.","family":"Walker","sequence":"first","affiliation":[{"name":"Biology Department, Saint Louis University, Saint Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary C.","family":"Port","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Caparon","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-2474","authenticated-orcid":false,"given":"Blythe E.","family":"Janowiak","sequence":"additional","affiliation":[{"name":"Biology Department, Saint Louis University, Saint Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2012.10.006"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414326200"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.6.1454-1459.1998"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01393-12"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi052483v"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2012.09.008"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.8.5098-5106.2001"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00756-06"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.7.2131-2135.1996"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14029"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.142.1.165"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/152.2.323"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182380799"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.133.3.1126-1129.1978"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.17.2056"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406143101"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.7.1990-1995.1996"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509517200"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.654582"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jobm.201300805"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.65.12.5600-5603.1999"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6976.12071"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.95.6.2131-2138.1968"},{"key":"e_1_3_3_25_2","volume-title":"The chemistry of chlorine, bromine, iodine, and astatine","author":"Downs AJ","year":"1975","unstructured":"Downs AJ, Adams CJ. 1975. 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