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These hardy bacteria have evolved to survive and replicate in host cells, particularly macrophages, and have developed a specialized quorum sensing system that is essential for navigating intracellular life. Moreover, successful infection of the host is dependent upon elements of the\n                      <jats:italic toggle=\"yes\">Brucella<\/jats:italic>\n                      quorum sensing system. While quorum sensing is a thoroughly well-defined process in many Gram-negative bacteria, several unique features in the quorum sensing pathway have evolved that set\n                      <jats:italic toggle=\"yes\">Brucella<\/jats:italic>\n                      apart from more established model organisms. The current review is aimed at describing the paradigmatic aspects of\n                      <jats:italic toggle=\"yes\">Brucella<\/jats:italic>\n                      quorum sensing, while also underscoring the nuance and distinctiveness of quorum sensing in the brucellae, and we discuss important questions that remain unanswered in the field.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/jb.00388-25","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T14:04:32Z","timestamp":1762956272000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["The atypical quorum sensing system of classical\n                    <i>Brucella<\/i>\n                    species"],"prefix":"10.1128","volume":"207","author":[{"given":"Mitchell T.","family":"Caudill","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/010prmy50","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for One Health Research, Department of Biomedical Sciences and Pathobiology, VA-MD College of Veterinary Medicine, Virginia Tech","place":["Blacksburg, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3793-8804","authenticated-orcid":true,"given":"Clayton C.","family":"Caswell","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/010prmy50","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for One Health Research, Department of Biomedical Sciences and Pathobiology, VA-MD College of Veterinary Medicine, Virginia Tech","place":["Blacksburg, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuaa045"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.00438-23"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01091-13"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.02049"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.10.3244-3249.1997"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01581-08"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11030377"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.6.3210-3218.2000"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10040813"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/avj.12925"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1052"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evx137"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47330-0"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207749"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.03.003"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr1000817"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr100064s"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-146-10-2469"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-10-167"},{"key":"e_1_3_2_21_2","volume-title":"Brucella: molecular microbiology and genomics","author":"Terwagne M","year":"2012","unstructured":"Terwagne M, Bonnot S, Letesson JJ. 2012. Brucella quorum sensing: much more than sensing quorum. In L\u00f3pez-Goni I, O\u2019Callaghan D (ed), Brucella: molecular microbiology and genomics. 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