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Previous studies have shown that the causative bacterium,\n                    <jats:named-content content-type=\"genus-species\">Borrelia burgdorferi<\/jats:named-content>\n                    , methylates its genome using restriction modification systems that enable the distinction from foreign DNA. Although much research has focused on the regulation of gene expression in\n                    <jats:named-content content-type=\"genus-species\">B. burgdorferi<\/jats:named-content>\n                    , the effect of DNA methylation on gene regulation has not been evaluated. The current study characterizes the patterns of DNA methylation by restriction modification systems in\n                    <jats:named-content content-type=\"genus-species\">B. burgdorferi<\/jats:named-content>\n                    and evaluates the resulting effects on gene regulation in this important pathogen.\n                  <\/jats:p>","DOI":"10.1128\/jb.00395-18","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T09:38:51Z","timestamp":1537781931000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["DNA Methylation by Restriction Modification Systems Affects the Global Transcriptome Profile in Borrelia burgdorferi"],"prefix":"10.1128","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1954-2443","authenticated-orcid":false,"given":"Timothy","family":"Casselli","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, 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