{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:09:10Z","timestamp":1790629750851,"version":"4.1.0"},"reference-count":74,"publisher":"American Society for Microbiology","issue":"19","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["2R15AI109566"],"award-info":[{"award-number":["2R15AI109566"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Chlamydia<\/jats:named-content>\n            is a significant cause of disease in humans, including sexually transmitted infections, the ocular infection trachoma, and pneumonia. Despite the critical roles of protein phosphatases in bacterial physiology, their function in pathogenesis is less clear. Our findings demonstrate that CppA, a broad-specificity type 2C protein phosphatase (PP2C), is critical for chlamydial development and further substantiate reversible phosphorylation as a key regulatory mechanism in\n            <jats:named-content content-type=\"genus-species\">Chlamydia<\/jats:named-content>\n            . Additionally, our work highlights the potential of CppA to serve as a novel target for future therapeutic strategies and supports the feasibility of designing more potent PP2C phosphatase inhibitors for\n            <jats:named-content content-type=\"genus-species\">Chlamydia<\/jats:named-content>\n            and other pathogenic bacteria.\n          <\/jats:p>","DOI":"10.1128\/jb.00419-18","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T10:12:39Z","timestamp":1532427159000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Inhibition of the Protein Phosphatase CppA Alters Development of Chlamydia trachomatis"],"prefix":"10.1128","volume":"200","author":[{"given":"Ja E.","family":"Claywell","sequence":"first","affiliation":[{"name":"Department of Microbiology, Southern Illinois University, Carbondale, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea M.","family":"Matschke","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Southern Illinois University, Carbondale, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5691-7876","authenticated-orcid":false,"given":"Kyle N.","family":"Plunkett","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1663-8389","authenticated-orcid":false,"given":"Derek J.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Southern Illinois University, Carbondale, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.62.081307.162818"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1865-1682.2011.01274.x"},{"key":"e_1_3_3_4_2","unstructured":"World Health Organization. 2017. Trachoma fact sheet. World Health Organization Geneva Switzerland. http:\/\/www.who.int\/mediacentre\/factsheets\/fs382\/en\/."},{"key":"e_1_3_3_5_2","unstructured":"World Health Organization. 2016. Sexually transmitted infections (STIs). World Health Organization Geneva Switzerland. http:\/\/www.who.int\/mediacentre\/factsheets\/fs110\/en\/."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62182-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/652397"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2012.10.009"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2015.05.006"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2002.0629"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsre.2005.03.002"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.30"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00627.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703218104"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2016.06.005"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr000230w"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2011_2258"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3036"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07228.x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr000247e"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2011.00314.x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M110.001594"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2002.tb10978.x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00042-10"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2011.0424"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M700311-MCP200"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M600464-MCP200"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200800655"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201000649"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr900612v"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000116"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.10.5772-5784.2003"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00893-07"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-218"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00025-16"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.03.014"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2008.01094.x"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01221-09"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011071"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083989"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201500003"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0305-0491(91)90139-5"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-4959(01)00391-8"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200401044"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07877.x"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149011"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1331135100"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1700308"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6968.12189"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1159\/000089648"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1586\/14789450.5.4.619"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2007.08.006"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi034074+"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi500428j"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017871"},{"key":"e_1_3_3_56_2","unstructured":"Reference deleted."},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200604205"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2016.06.014"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules191016489"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00225-18"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.041202-0"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04551.x"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02362.x"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.231254998"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1505297112"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.22.6109-6114.2002"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.44.2.479-485.1984"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13630"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002258"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780471729259.mc11a01s00"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.12.6754-6765.2003"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.12.6914-6923.2004"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.75"},{"key":"e_1_3_3_74_2","first-page":"95","article-title":"BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT","volume":"41","author":"Hall TA","year":"1999","unstructured":"Hall TA. 1999. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT. Nucleic Acids Symp Ser 41:95\u201398.","journal-title":"Nucleic Acids Symp Ser"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.1998.tb00369.x"}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.00419-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.00419-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T17:45:35Z","timestamp":1627580735000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JB.00419-18"}},"subtitle":[],"editor":[{"given":"Ann M.","family":"Stock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":74,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1128\/JB.00419-18"],"URL":"https:\/\/doi.org\/10.1128\/jb.00419-18","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"2018-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}