{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:48:24Z","timestamp":1791247704982,"version":"4.1.0"},"reference-count":66,"publisher":"American Society for Microbiology","issue":"15","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Type 1 fimbriae and flagella have been previously shown to contribute to the virulence of uropathogenic\n            <jats:italic>Escherichia coli<\/jats:italic>\n            (UPEC) within the urinary tract. In this study, the relationship between motility and type 1 fimbrial expression was tested for UPEC strain CFT073 by examining the phenotypic effect of fimbrial expression on motility and the effect that induction of motility has on type 1 fimbrial expression. While constitutive expression of type 1 fimbriae resulted in a significant decrease in motility and flagellin expression (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.0001), a loss of type 1 fimbrial expression did not result in increased motility. Additionally, hypermotility and flagellar gene over- and underexpression were not observed to affect the expression of type 1 fimbriae. Hence, it appeared that the relationship between type 1 fimbrial expression and motility is unidirectional, where the overexpression of type 1 fimbriae dramatically affects motility and flagellum expression but not vice versa. Moreover, the constitutive expression of type 1 fimbriae in UPEC cystitis isolate F11 and the laboratory strain\n            <jats:italic>E. coli<\/jats:italic>\n            K-12 MG1655 also resulted in decreased motility, suggesting that this phenomenon is not specific to CFT073 or UPEC in general. Lastly, by analyzing the repression of motility caused by constitutive type 1 fimbrial expression, it was concluded that the synthesis and presence of type 1 fimbriae at the bacterial surface is only partially responsible for the repression of motility, as evidenced by the partial restoration of motility in the CFT073\n            <jats:italic>fim<\/jats:italic>\n            L-ON \u0394\n            <jats:italic>fimAICDFGH<\/jats:italic>\n            mutant. Altogether, these data provide further insight into the complex interplay between type 1 fimbrial expression and flagellum-mediated motility.\n          <\/jats:p>","DOI":"10.1128\/jb.00434-07","type":"journal-article","created":{"date-parts":[[2007,5,19]],"date-time":"2007-05-19T14:27:13Z","timestamp":1179584833000},"page":"5523-5533","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":107,"title":["Complex Interplay between Type 1 Fimbrial Expression and Flagellum-Mediated Motility of Uropathogenic\n            <i>Escherichia coli<\/i>"],"prefix":"10.1128","volume":"189","author":[{"given":"M. Chelsea","family":"Lane","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy N.","family":"Simms","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry L. T.","family":"Mobley","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"5724","DOI":"10.1073\/pnas.82.17.5724","volume":"82","year":"1985","unstructured":"Abraham, J. M., C. S. Freitag, J. R. Clements, and B. I. Eisenstein. 1985. 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