{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:07:16Z","timestamp":1790424436922,"version":"4.1.0"},"reference-count":62,"publisher":"American Society for Microbiology","issue":"17","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Clinical and murine studies suggest that there is a differential pathogenicity of different genotypes of<jats:italic>Borrelia burgdorferi<\/jats:italic>, the spirochetal agent of Lyme disease. Comparative genome hybridization was used to explore the relationship between different genotypes. The chromosomes of all studied isolates were highly conserved (&gt;93%) with respect to both sequence and gene order. Plasmid sequences were substantially more diverse. Plasmids lp54, cp26, and cp32 were present in all tested isolates, and their sequences and gene order were conserved. The majority of linear plasmids showed variation both in terms of presence among different isolates and in terms of sequence and gene order. The data strongly imply that all<jats:italic>B. burgdorferi<\/jats:italic>clinical isolates contain linear plasmids related to each other, but the structure of these replicons may vary substantially from isolate to isolate. These alterations include deletions and presumed rearrangements that are likely to result in unique plasmid elements in many isolates. There is a strong correlation between complete genome hybridization profiles and other typing methods, which, in turn, also correlate to differences in pathogenicity. Because there is substantially less variation in the chromosomal and circular plasmid portions of the genome, the major differences in open reading frame content and genomic diversity among isolates are linear plasmid driven.<\/jats:p>","DOI":"10.1128\/jb.00459-06","type":"journal-article","created":{"date-parts":[[2006,8,21]],"date-time":"2006-08-21T17:14:16Z","timestamp":1156180456000},"page":"6124-6134","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":60,"title":["Comparative Genome Hybridization Reveals Substantial Variation among Clinical Isolates of<i>Borrelia burgdorferi<\/i>Sensu Stricto with Different Pathogenic Properties"],"prefix":"10.1128","volume":"188","author":[{"given":"Darya","family":"Terekhova","sequence":"first","affiliation":[{"name":"Departments of Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha","family":"Iyer","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary P.","family":"Wormser","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, New York 10595"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Immunology"},{"name":"Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, New York 10595"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.4049\/jimmunol.169.7.3847","volume":"169","year":"2002","unstructured":"Alitalo, A., T. Meri, H. Lankinen, I. Seppala, P. Lahdenne, P. S. Hefty, D. Akins, and S. Meri. 2002. Complement inhibitor factor H binding to Lyme disease spirochetes is mediated by inducible expression of multiple plasmid-encoded outer surface protein E paralogs. J. Immunol. 169 : 3847-3853.","journal-title":"J. Immunol."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.26.3.475-478.1988"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5419.1520"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1534\/genetics.104.028738","volume":"168","year":"2004","unstructured":"Brisson, D., and D. E. Dykhuizen. 2004. ospC diversity in Borrelia burgdorferi: different hosts are different niches. Genetics 168 : 713-722.","journal-title":"Genetics"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.7.2924-2931.2003"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1099\/mic.0.26944-0","volume":"150","year":"2004","unstructured":"Bunikis, J., U. Garpmo, J. Tsao, J. Berglund, D. Fish, and A. G. Barbour. 2004. Sequence typing reveals extensive strain diversity of the Lyme borreliosis agents Borrelia burgdorferi in North America and Borrelia afzelii in Europe. Microbiology 150 : 1741-1755.","journal-title":"Microbiology"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.11.3561-3569.2004"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.10.2769-2780.1995"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1046\/j.1365-2958.2000.01698.x","volume":"35","year":"2000","unstructured":"Casjens, S., N. Palmer, R. van Vugt, W. M. Huang, B. Stevenson, P. Rosa, R. Lathigra, G. Sutton, J. Peterson, R. J. Dodson, D. Haft, E. Hickey, M. Gwinn, O. White, and C. M. Fraser. 2000. A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi. Mol. Microbiol. 35 : 490-516.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.1.217-227.1997"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1365-2958.2005.04872.x","volume":"58","year":"2005","unstructured":"Chaconas, G. 2005. Hairpin telomeres and genome plasticity in Borrelia: all mixed up in the end. Mol. Microbiol. 58 : 625-635.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.2.553-563.2003"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.9.5438-5449.2005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/417459a"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1073\/pnas.042667999","volume":"99","year":"2002","unstructured":"Dziejman, M., E. Balon, D. Boyd, C. M. Fraser, J. F. Heidelberg, and J. J. Mekalanos. 2002. Comparative genomic analysis of Vibrio cholerae: genes that correlate with cholera endemic and pandemic disease. Proc. Natl. Acad. Sci. USA 99 : 1556-1561.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.19.5479-5490.2002"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/37551"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"6038","DOI":"10.1093\/nar\/gkh953","volume":"32","year":"2004","unstructured":"Glockner, G., R. Lehmann, A. Romualdi, S. Pradella, U. Schulte-Spechtel, M. Schilhabel, B. Wilske, J. Suhnel, and M. Platzer. 2004. Comparative analysis of the Borrelia garinii genome. Nucleic Acids Res. 32 : 6038-6046.","journal-title":"Nucleic Acids Res."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.9.2546-2551.2002"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/8.1.11"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.3.1967-1972.2006"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"12420","DOI":"10.1073\/pnas.1635213100","volume":"100","year":"2003","unstructured":"Hsu, T., S. M. Hingley-Wilson, B. Chen, M. Chen, A. Z. Dai, P. M. Morin, C. B. Marks, J. Padiyar, C. Goulding, M. Gingery, D. Eisenberg, R. G. Russell, S. C. Derrick, F. M. Collins, S. L. Morris, C. H. King, and W. R. Jacobs, Jr. 2003. The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue. Proc. Natl. Acad. Sci. USA 100 : 12420-12425.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/86730","volume":"19","year":"2001","unstructured":"Hughes, T. R., M. Mao, A. R. Jones, J. Burchard, M. J. Marton, K. W. Shannon, S. M. Lefkowitz, M. Ziman, J. M. Schelter, M. R. Meyer, S. Kobayashi, C. Davis, H. Dai, Y. D. He, S. B. Stephaniants, G. Cavet, W. L. Walker, A. West, E. Coffey, D. D. Shoemaker, R. Stoughton, A. P. Blanchard, S. H. Friend, and P. S. Linsley. 2001. Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer. Nat. Biotechnol. 19 : 342-347.","journal-title":"Nat. Biotechnol."},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1172\/JCI11450","volume":"107","year":"2001","unstructured":"Israel, D. A., N. Salama, C. N. Arnold, S. F. Moss, T. Ando, H. P. Wirth, K. T. Tham, M. Camorlinga, M. J. Blaser, S. Falkow, and R. M. Peek, Jr. 2001. Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses. J. Clin. Investig. 107 : 611-620.","journal-title":"J. Clin. Investig."},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"14625","DOI":"10.1073\/pnas.251551698","volume":"98","year":"2001","unstructured":"Israel, D. A., N. Salama, U. Krishna, U. M. Rieger, J. C. Atherton, S. Falkow, and R. M. Peek, Jr. 2001. Helicobacter pylori genetic diversity within the gastric niche of a single human host. Proc. Natl. Acad. Sci. USA 98 : 14625-14630.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.7.3699-3706.2003"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.8.2954-2957.2001"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1093\/nar\/28.22.4552","volume":"28","year":"2000","unstructured":"Kane, M. D., T. A. Jatkoe, C. R. Stumpf, J. Lu, J. D. Thomas, and S. J. Madore. 2000. Assessment of the sensitivity and specificity of oligonucleotide (50mer) microarrays. Nucleic Acids Res. 28 : 4552-4557.","journal-title":"Nucleic Acids Res."},{"key":"e_1_3_2_30_2","unstructured":"Genome Biol. 2002 3"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.molcel.2005.02.025","volume":"17","year":"2005","unstructured":"Kobryn, K., and G. Chaconas. 2005. Fusion of hairpin telomeres by the B. burgdorferi telomere resolvase ResT implications for shaping a genome in flux. Mol. Cell 17 : 783-791.","journal-title":"Mol. Cell"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.16.5442-5449.2004"},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF00196683","volume":"183","year":"1994","unstructured":"Lebech, A. M., K. Hansen, B. Wilske, and M. Theisen. 1994. Taxonomic classification of 29 Borrelia burgdorferi strains isolated from patients with Lyme borreliosis: a comparison of five different phenotypic and genotypic typing schemes. Med. Microbiol. Immunol. (Berlin) 183 : 325-341.","journal-title":"Med. Microbiol. Immunol. (Berlin)"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.27.4.636-639.1989"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.3.589-595.1995"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.5.1306-1309.1996"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.11.3357-3361.1996"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.4.926-932.1993"},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/infdis\/175.1.98","volume":"175","year":"1997","unstructured":"Mathiesen, D. A., J. H. Oliver, Jr., C. P. Kolbert, E. D. Tullson, B. J. Johnson, G. L. Campbell, P. D. Mitchell, K. D. Reed, S. R. Telford III, J. F. Anderson, R. S. Lane, and D. H. Persing. 1997. Genetic heterogeneity of Borrelia burgdorferi in the United States. J. Infect. Dis. 175 : 98-107.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0934-8840(98)80124-2","volume":"287","year":"1998","unstructured":"O'Connell, S., M. Granstrom, J. S. Gray, and G. Stanek. 1998. Epidemiology of European Lyme borreliosis. Zentralbl. Bakteriol. 287 : 229-240.","journal-title":"Zentralbl. Bakteriol."},{"key":"e_1_3_2_41_2","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1099\/13500872-140-11-2931","volume":"140","year":"1994","unstructured":"Ojaimi, C., B. E. Davidson, G. Saint, and I. G. Old. 1994. Conservation of gene arrangement and an unusual organization of rRNA genes in the linear chromosomes of the Lyme disease spirochaetes Borrelia burgdorferi, B. garinii and B. afzelii. Microbiology 140 : 2931-2940.","journal-title":"Microbiology"},{"key":"e_1_3_2_42_2","first-page":"1","volume":"49","year":"2000","unstructured":"Orloski, K. A., E. B. Hayes, G. L. Campbell, and D. T. Dennis. 2000. Surveillance for Lyme disease\u2014United States, 1992-1998. Morb. Mortal. Wkly. Rep. CDC Surveill. Summ. 49 : 1-11.","journal-title":"Morb. Mortal. Wkly. Rep. CDC Surveill. Summ."},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.9.2476-2480.2000"},{"key":"e_1_3_2_44_2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/35054089","volume":"409","year":"2001","unstructured":"Perna, N. T., G. Plunkett III, V. Burland, B. Mau, J. D. Glasner, D. J. Rose, G. F. Mayhew, P. S. Evans, J. Gregor, H. A. Kirkpatrick, G. Posfai, J. Hackett, S. Klink, A. Boutin, Y. Shao, L. Miller, E. J. Grotbeck, N. W. Davis, A. Lim, E. T. Dimalanta, K. D. Potamousis, J. Apodaca, T. S. Anantharaman, J. Lin, G. Yen, D. C. Schwartz, R. A. Welch, and F. R. Blattner. 2001. Genome sequence of enterohaemorrhagic Escherichia coli O157:H7. Nature 409 : 529-533.","journal-title":"Nature"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.25.3.557-558.1987"},{"key":"e_1_3_2_46_2","doi-asserted-by":"crossref","first-page":"14150","DOI":"10.1073\/pnas.0402745101","volume":"101","year":"2004","unstructured":"Qiu, W. G., S. E. Schutzer, J. F. Bruno, O. Attie, Y. Xu, J. J. Dunn, C. M. Fraser, S. R. Casjens, and B. J. Luft. 2004. Genetic exchange and plasmid transfers in Borrelia burgdorferi sensu stricto revealed by three-way genome comparisons and multilocus sequence typing. Proc. Natl. Acad. Sci. USA 101 : 14150-14155.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.6.1397"},{"key":"e_1_3_2_48_2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature01586","volume":"423","year":"2003","unstructured":"Read, T. D., S. N. Peterson, N. Tourasse, L. W. Baillie, I. T. Paulsen, K. E. Nelson, H. Tettelin, D. E. Fouts, J. A. Eisen, S. R. Gill, E. K. Holtzapple, O. A. Okstad, E. Helgason, J. Rilstone, M. Wu, J. F. Kolonay, M. J. Beanan, R. J. Dodson, L. M. Brinkac, M. Gwinn, R. T. DeBoy, R. Madpu, S. C. Daugherty, A. S. Durkin, D. H. Haft, W. C. Nelson, J. D. Peterson, M. Pop, H. M. Khouri, D. Radune, J. L. Benton, Y. Mahamoud, L. Jiang, I. R. Hance, J. F. Weidman, K. J. Berry, R. D. Plaut, A. M. Wolf, K. L. Watkins, W. C. Nierman, A. Hazen, R. Cline, C. Redmond, J. E. Thwaite, O. White, S. L. Salzberg, B. Thomason, A. M. Friedlander, T. M. Koehler, P. C. Hanna, A. B. Kolsto, and C. M. Fraser. 2003. The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria. Nature 423 : 81-86.","journal-title":"Nature"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.5.2192-2195.1993"},{"key":"e_1_3_2_50_2","doi-asserted-by":"crossref","first-page":"14668","DOI":"10.1073\/pnas.97.26.14668","volume":"97","year":"2000","unstructured":"Salama, N., K. Guillemin, T. K. McDaniel, G. Sherlock, L. Tompkins, and S. Falkow. 2000. A whole-genome microarray reveals genetic diversity among Helicobacter pylori strains. Proc. Natl. Acad. Sci. USA 97 : 14668-14673.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_51_2","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1099\/00221287-139-10-2445","volume":"139","year":"1993","unstructured":"Samuels, D. S., R. T. Marconi, and C. F. Garon. 1993. Variation in the size of the ospA-containing linear plasmid, but not the linear chromosome, among the three Borrelia species associated with Lyme disease. J. Gen. Microbiol. 139 : 2445-2449.","journal-title":"J. Gen. Microbiol."},{"key":"e_1_3_2_52_2","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1099\/mic.0.28099-0","volume":"151","year":"2005","unstructured":"Stabler, R. A., G. L. Marsden, A. A. Witney, Y. Li, S. D. Bentley, C. M. Tang, and J. Hinds. 2005. Identification of pathogen-specific genes through microarray analysis of pathogenic and commensal Neisseria species. Microbiology 151 : 2907-2922.","journal-title":"Microbiology"},{"key":"e_1_3_2_53_2","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1073\/pnas.91.7.2378","volume":"91","year":"1994","unstructured":"Steere, A. C. 1994. Lyme disease: a growing threat to urban populations. Proc. Natl. Acad. Sci. USA 91 : 2378-2383.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_54_2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1056\/NEJM198303313081301","volume":"308","year":"1983","unstructured":"Steere, A. C., R. L. Grodzicki, A. N. Kornblatt, J. E. Craft, A. G. Barbour, W. Burgdorfer, G. P. Schmid, E. Johnson, and S. E. Malawista. 1983. The spirochetal etiology of Lyme disease. N. Engl. J. Med. 308 : 733-740.","journal-title":"N. Engl. J. Med."},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.7.1797-1804.1995"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.7.4303-4312.2001"},{"key":"e_1_3_2_57_2","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1086\/343043","volume":"186","year":"2002","unstructured":"Wang, G., C. Ojaimi, H. Wu, V. Saksenberg, R. Iyer, D. Liveris, S. A. McClain, G. P. Wormser, and I. Schwartz. 2002. Disease severity in a murine model of lyme borreliosis is associated with the genotype of the infecting Borrelia burgdorferi sensu stricto strain. J. Infect. Dis. 186 : 782-791.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.4.633"},{"key":"e_1_3_2_59_2","doi-asserted-by":"crossref","first-page":"8484","DOI":"10.1073\/pnas.0832438100","volume":"100","year":"2003","unstructured":"Wolfgang, M. C., B. R. Kulasekara, X. Liang, D. Boyd, K. Wu, Q. Yang, C. G. Miyada, and S. Lory. 2003. Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 100 : 8484-8489.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_60_2","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1086\/314922","volume":"180","year":"1999","unstructured":"Wormser, G. P., D. Liveris, J. Nowakowski, R. B. Nadelman, L. F. Cavaliere, D. McKenna, D. Holmgren, and I. Schwartz. 1999. Association of specific subtypes of Borrelia burgdorferi with hematogenous dissemination in early Lyme disease. J. Infect. Dis. 180 : 720-725.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.3.1856-1860.2005"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.12.3115-3122.1993"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.12.3109-3114.1993"}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.00459-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.00459-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T01:48:49Z","timestamp":1707184129000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JB.00459-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":62,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1128\/JB.00459-06"],"URL":"https:\/\/doi.org\/10.1128\/jb.00459-06","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9]]},"assertion":[{"value":"2006-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-06-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}