{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:33:52Z","timestamp":1785429232780,"version":"3.56.0"},"reference-count":125,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"NIAID NRSA Pre-Doctoral F31 Fellowship","award":["AI172335"],"award-info":[{"award-number":["AI172335"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2026,4,23]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                      is a highly versatile opportunistic pathogen and a major cause of acute, chronic, and even lifelong respiratory infections in people with cystic fibrosis. It can also cause corneal infections, burn\/wound infections, and bacteremia.\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      is often found in human-associated environments such as hospitals, where it is a frequent cause of nosocomial catheter-associated urinary tract infections and ventilator-associated pneumonia. As a nosocomial pathogen, a major environmental change associated with transmission is the change from room or ambient temperature to human body temperature.\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      is highly studied for its regulatory and adaptive responses to environmental stimuli, such as low iron conditions or the presence of antibiotics, but temperature regulation, or thermoregulation, is relatively understudied, particularly at a mechanistic level. This review explores the current understanding of mechanisms of global, transcriptional, post-transcriptional, and post-translational thermoregulation in\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      , with a discussion on gaps in the field\u2019s knowledge and directions for future research. More mechanistic studies of thermoregulation inspired by the open questions presented here will improve our understanding of how\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      adapts to different temperatures.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/jb.00495-25","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:02:10Z","timestamp":1773234130000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Mechanisms of thermoregulation in\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1128","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7493-942X","authenticated-orcid":false,"given":"Rachel E.","family":"Robinson","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03czfpz43","id-type":"ROR","asserted-by":"publisher"}],"name":"Microbiology and Molecular Genetics Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University","place":["Atlanta, USA"]},{"id":[{"id":"https:\/\/ror.org\/03czfpz43","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Pulmonary, Asthma, Cystic Fibrosis, and Sleep, Department of Pediatrics, Emory University School of Medicine","place":["Atlanta, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5285-5188","authenticated-orcid":true,"given":"Joanna B.","family":"Goldberg","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03czfpz43","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Pulmonary, Asthma, Cystic Fibrosis, and Sleep, Department of Pediatrics, Emory University School of Medicine","place":["Atlanta, USA"]},{"id":[{"id":"https:\/\/ror.org\/02gars961","id-type":"ROR","asserted-by":"publisher"}],"name":"Emory+Children\u2019s Center for Cystic Fibrosis and Airway Disease Research, Emory University School of Medicine","place":["Atlanta, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-025-01193-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.13010"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00053"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.152.2.636-642.1982"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2018.11.013"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415779"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2019.07.002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000370"},{"key":"e_1_3_2_10_2","unstructured":"Centers for Disease Control and Prevention (U.S.). 2019. 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