{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:28:06Z","timestamp":1780428486342,"version":"3.54.1"},"reference-count":64,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19AI109776"],"award-info":[{"award-number":["U19AI109776"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["102908\/Z\/13\/Z"],"award-info":[{"award-number":["102908\/Z\/13\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["221924\/Z\/20\/Z"],"award-info":[{"award-number":["221924\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2022,3,15]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Shigella sonnei<\/jats:named-content>\n            is the major cause of shigellosis in high-income and industrializing countries and is an emerging, multidrug-resistant pathogen. A significant challenge when studying this bacterium is that it spontaneously becomes avirulent during growth in the laboratory through loss of its virulence plasmid (pINV).\n          <\/jats:p>","DOI":"10.1128\/jb.00519-21","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T16:24:18Z","timestamp":1641227058000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Maintenance of the Shigella sonnei Virulence Plasmid Is Dependent on Its Repertoire and Amino Acid Sequence of Toxin-Antitoxin Systems"],"prefix":"10.1128","volume":"204","author":[{"given":"Jessica E.","family":"Martyn","sequence":"first","affiliation":[{"name":"Sir William Dunn School of Pathology, University of Oxford, United Kingdom"},{"name":"Biologie des Bact\u00e9ries Intracellulaires, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Pilla","sequence":"additional","affiliation":[{"name":"Sir William Dunn School of Pathology, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hollingshead","sequence":"additional","affiliation":[{"name":"Sir William Dunn School of Pathology, University of Oxford, United Kingdom"},{"name":"Evotec, Abingdon, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7352-1630","authenticated-orcid":true,"given":"Kristoffer S.","family":"Winther","sequence":"additional","affiliation":[{"name":"Biomolecular Sciences Department of Biology, Centre for Bacterial Stress Response and Persistence (BASP), University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9287-8053","authenticated-orcid":true,"given":"Susan","family":"Lea","sequence":"additional","affiliation":[{"name":"Sir William Dunn School of Pathology, University of Oxford, United Kingdom"},{"name":"Center for Structural Biology, Center for Cancer Research (CCR), National Cancer Institute at Frederick, Fort Detrick, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"McVicker","sequence":"additional","affiliation":[{"name":"Sir William Dunn School of Pathology, University of Oxford, United Kingdom"},{"name":"Antimicrobial Resistance, Omics and Microbiota Group, Department of Biosciences, Nottingham Trent University, Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8366-3245","authenticated-orcid":true,"given":"Christoph M.","family":"Tang","sequence":"additional","affiliation":[{"name":"Sir William Dunn School of Pathology, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30276-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu468"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60844-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33296-8"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-01905-9"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22700-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1286-4579(02)01637-4"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.49.1.164-171.1985"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.170.6.2480-2484.1988"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00032-07"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00064"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/358167a0"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.51.2.461-469.1986"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.29.1.207-214.1980"},{"key":"e_1_3_3_16_2","first-page":"879","article-title":"Correlation between the loss of plasmid DNA and the transition from virulent phase I to avirulent phase II in Shigella sonnei","volume":"290","author":"Sansonetti P","year":"1980","unstructured":"Sansonetti P, David M, Toucas M. 1980. Correlation between the loss of plasmid DNA and the transition from virulent phase I to avirulent phase II in Shigella sonnei. C R Seances Acad Sci D 290:879\u2013882.","journal-title":"C R Seances Acad Sci D"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.34.1.75-83.1981"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.204"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.9.4572-4576.1998"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2369"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134478"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.8.2768-2773.2005"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.10.3116"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04459.x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0031-2"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008931"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007014"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.24.2.580-582.1979"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.43.1.397-401.1984"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.18.1.94-98.1977"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.51.2.470-475.1986"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.9.3686-3692.1997"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plasmid.2005.03.002"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1998.2416"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.10.024"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019587108"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks029"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14225"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41548-9"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.02179.x"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.9.2416-2421.2000"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.11.3670-3675.1997"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00993.x"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.5.3271-3285.2001"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.1.175-182.1992"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2019.01.004"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.8.4414-4423.2002"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004749"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02654-19"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10091079"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.4.2016-2021.2002"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.04.115"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.2.4.17042"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.120163297"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(85)90120-9"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.4.1648"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7347"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.14.4121-4130.1995"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3796"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798317017235"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr535"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807021206"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910045749"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910007493"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909052925"}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jb.00519-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jb.00519-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T15:02:53Z","timestamp":1647356573000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jb.00519-21"}},"subtitle":[],"editor":[{"given":"Laurie E.","family":"Comstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,3,15]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3,15]]}},"alternative-id":["10.1128\/jb.00519-21"],"URL":"https:\/\/doi.org\/10.1128\/jb.00519-21","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,15]]},"assertion":[{"value":"2021-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00519-21"}}