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Being fundamentally similar to natural selection, the fitness of resistant mutants is a key parameter to consider in the evolutionary dynamics of antimicrobial resistance (AMR). Various intrinsic and extrinsic factors modulate the fitness of resistant bacteria. This study demonstrated that Lon, a bacterial master regulator protease, influences drug tolerance and resistance. Lon is a key regulator of several fundamental processes in bacteria, including cytokinesis. I demonstrated that Lon deficiency produces highly contingent phenotypes in\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            challenged with trimethoprim and can expand the mutational repertoire available to\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            to evolve resistance. This multipronged influence of Lon on drug resistance provides an illustrative instance of how master regulators shape the response of bacteria to antibiotics.\n          <\/jats:p>","DOI":"10.1128\/jb.00561-19","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T12:32:28Z","timestamp":1573648348000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["Highly Contingent Phenotypes of Lon Protease Deficiency in Escherichia coli upon Antibiotic Challenge"],"prefix":"10.1128","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2947-3931","authenticated-orcid":false,"given":"Nishad","family":"Matange","sequence":"first","affiliation":[{"name":"Department of Biology, Indian Institute of Science Education and Research, Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/evo.13111"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.119.301834"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04059-1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/315708"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaj2191"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10333"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800944105"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1568-7864(03)00024-7"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1205357109"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02756"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2019.01.005"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.8.4931"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.148.1.265-273.1981"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.2.358"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01128-06"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06694.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201800080"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep20519"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01964-17"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03952.x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000271"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12429"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049123"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2016.138"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi060542e"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.71.2.690-696.2003"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.184.1.224-232.2002"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.11.004"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601441113"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009233"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20180249"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8385"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1034"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep41284"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005612"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2010.07.009"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1097-2765(01)00209-x"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1670908"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-11-14"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.34"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.08.045"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.113.152306"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002158"},{"key":"e_1_3_3_45_2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/genetics\/160.3.823","article-title":"Predicting evolutionary potential: in vitro evolution accurately reproduces natural evolution of the tem beta-lactamase","volume":"160","author":"Barlow M","year":"2002","unstructured":"Barlow M, Hall BG. 2002. 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