{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:18:13Z","timestamp":1792171093529,"version":"4.4.0"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"13","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Among enteric pathogens,\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Salmonella enterica<\/jats:named-content>\n            serovar Typhi is responsible for the largest number of food-borne outbreaks and fatalities. The ability of the pathogen to cause systemic infection for extended durations leads to a high cost of disease control. Chronic carriers play important roles in the evolution of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Salmonella<\/jats:named-content>\n            Typhi; therefore, identification and in-depth characterization of isolates from clinical cases and carriers, especially those from zones of endemicity where the pathogen has not been extensively studied, are necessary. Here, we describe the genome sequence of the highly virulent\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Salmonella<\/jats:named-content>\n            Typhi strain BL196\/05 isolated during the outbreak of typhoid in Kelantan, Malaysia, in 2005. The whole-genome sequence and comparative genomics of this strain should enable us to understand the virulence mechanisms and evolutionary dynamics of this pathogen in Malaysia and elsewhere.\n          <\/jats:p>","DOI":"10.1128\/jb.00581-12","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T22:23:10Z","timestamp":1339453390000},"page":"3565-3566","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Genetic Fine Structure of a Salmonella enterica Serovar Typhi Strain Associated with the 2005 Outbreak of Typhoid Fever in Kelantan, Malaysia"],"prefix":"10.1128","volume":"194","author":[{"given":"Ramani","family":"Baddam","sequence":"first","affiliation":[{"name":"Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narender","family":"Kumar","sequence":"additional","affiliation":[{"name":"Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwai-Lin","family":"Thong","sequence":"additional","affiliation":[{"name":"Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia"},{"name":"Laboratory of Biomedical Science and Molecular Microbiology, UMBIO Research Cluster, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Tein","family":"Ngoi","sequence":"additional","affiliation":[{"name":"Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia"},{"name":"Laboratory of Biomedical Science and Molecular Microbiology, UMBIO Research Cluster, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy Shuan Ju","family":"Teh","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Science and Molecular Microbiology, UMBIO Research Cluster, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kien-Pong","family":"Yap","sequence":"additional","affiliation":[{"name":"Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia"},{"name":"Laboratory of Biomedical Science and Molecular Microbiology, UMBIO Research Cluster, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lay-Ching","family":"Chai","sequence":"additional","affiliation":[{"name":"Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia"},{"name":"Laboratory of Biomedical Science and Molecular Microbiology, UMBIO Research Cluster, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiruvayipati Suma","family":"Avasthi","sequence":"additional","affiliation":[{"name":"Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India"},{"name":"Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niyaz","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India"},{"name":"Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1159\/000329786","article-title":"Coevolution and adaptation of Helicobacter pylori and the case for \u2018functional molecular infection epidemiology\u2019","volume":"20","author":"Ahmed N","year":"2011","unstructured":"AhmedN. 2011. Coevolution and adaptation of Helicobacter pylori and the case for \u2018functional molecular infection epidemiology\u2019. Med. Princ. Pract. 20:497\u2013503.","journal-title":"Med. Princ. 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