{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:06:59Z","timestamp":1790665619443,"version":"4.1.0"},"reference-count":87,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T00:00:00Z","timestamp":1552435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100009941","name":"Ministry of Defence","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>\n            The intracellular bacterial pathogen\n            <jats:named-content content-type=\"genus-species\">Francisella tularensis<\/jats:named-content>\n            causes a disease in humans characterized by the rapid onset of nonspecific symptoms such as swollen lymph glands, fever, and headaches.\n            <jats:named-content content-type=\"genus-species\">F. tularensis<\/jats:named-content>\n            is one of the most infectious bacteria known and following pulmonary exposure can have a mortality rate exceeding 50% if left untreated. The low infectious dose of this organism and concerns surrounding its potential as a biological weapon have heightened the need for effective and safe therapies. To expand the repertoire of targets for therapeutic development, we initiated a genome-wide analysis. This study has identified genes that are important for\n            <jats:named-content content-type=\"genus-species\">F. tularensis<\/jats:named-content>\n            under\n            <jats:italic>in vitro<\/jats:italic>\n            and\n            <jats:italic>in vivo<\/jats:italic>\n            conditions, providing candidates that can be evaluated for vaccine or antibacterial development.\n          <\/jats:p>","DOI":"10.1128\/jb.00630-18","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T11:34:34Z","timestamp":1547552074000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Global Analysis of Genes Essential for Francisella tularensis Schu S4 Growth\n            <i>In Vitro<\/i>\n            and for Fitness during Competitive Infection of Fischer 344 Rats"],"prefix":"10.1128","volume":"201","author":[{"given":"Philip 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