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Here, we present transcriptional and phenotypic differences of\n            <jats:named-content content-type=\"genus-species\">A. pleuropneumoniae<\/jats:named-content>\n            grown in different chemically defined media in the absence of (p)ppGpp. We show that the deprivation of branched-chain amino acids (BCAAs) does not elicit a change in the basal-level (p)ppGpp, but this level is sufficient to regulate the expression of BCAA biosynthesis. The mechanism found in\n            <jats:named-content content-type=\"genus-species\">A. pleuropneumoniae<\/jats:named-content>\n            is different from that of the model organism\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            but similar to that found in some Gram-positive bacteria. This study not only broadens the research scope of (p)ppGpp but also further validates the complexity and multiplicity of (p)ppGpp regulation in microorganisms that occupy different biological niches.\n          <\/jats:p>","DOI":"10.1128\/jb.00640-19","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T10:55:33Z","timestamp":1580727333000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Basal-Level Effects of (p)ppGpp in the Absence of Branched-Chain Amino Acids in Actinobacillus pleuropneumoniae"],"prefix":"10.1128","volume":"202","author":[{"given":"Gang","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Veterinary Biotechnology, Division of Bacterial Diseases, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 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