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Vegetative cells of this species produce anthrax toxin proteins and S-layer components during infection of mammalian hosts. So far, how the expression of these virulence factors is regulated remains largely unknown. Our results suggest that excess elevated c-di-AMP levels inhibit bacterial growth and reduce expression of S-layer components and anthracis toxins as well as reduce virulence in a mouse model of disease. These results indicate that c-di-AMP signaling plays crucial roles in\n            <jats:named-content content-type=\"genus-species\">B. anthracis<\/jats:named-content>\n            biology and disease.\n          <\/jats:p>","DOI":"10.1128\/jb.00653-19","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T14:16:00Z","timestamp":1581603360000},"update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Increased Excess Intracellular Cyclic di-AMP Levels Impair Growth and Virulence of Bacillus anthracis"],"prefix":"10.1128","volume":"202","author":[{"given":"Jia","family":"Hu","sequence":"first","affiliation":[{"name":"Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaobo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wuhan Institute 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