{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T19:53:00Z","timestamp":1723405980338},"reference-count":27,"publisher":"American Society for Microbiology","issue":"17","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Anthrax toxin and capsule, determinants for successful infection by\n            <jats:italic>Bacillus anthracis<\/jats:italic>\n            , are encoded on the virulence plasmids pXO1 and pXO2, respectively. Each of these plasmids also encodes proteins that are highly homologous to the signal sensor domain of a chromosomally encoded major sporulation sensor histidine kinase (BA2291) in this organism.\n            <jats:italic>B. anthracis<\/jats:italic>\n            Sterne overexpressing the plasmid pXO2-61-encoded signal sensor domain exhibited a significant decrease in sporulation that was suppressed by the deletion of the BA2291 gene. Expression of the sensor domains from the pXO1-118 and pXO2-61 genes in\n            <jats:italic>Bacillus subtilis<\/jats:italic>\n            strains carrying the\n            <jats:italic>B. anthracis<\/jats:italic>\n            sporulation sensor kinase BA2291 gene resulted in BA2291-dependent inhibition of sporulation. These results indicate that sporulation sensor kinase BA2291 is converted from an activator to an inhibitor of sporulation in its native host by the virulence plasmid-encoded signal sensor domains. We speculate that activation of these signal sensor domains contributes to the initiation of\n            <jats:italic>B. anthracis<\/jats:italic>\n            sporulation in the bloodstream of its infected host, a salient characteristic in the virulence of this organism, and provides an additional role for the virulence plasmids in anthrax pathogenesis.\n          <\/jats:p>","DOI":"10.1128\/jb.00656-06","type":"journal-article","created":{"date-parts":[[2006,8,21]],"date-time":"2006-08-21T17:14:16Z","timestamp":1156180456000},"page":"6354-6360","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Sensor Domains Encoded in\n            <i>Bacillus anthracis<\/i>\n            Virulence Plasmids Prevent Sporulation by Hijacking a Sporulation Sensor Histidine Kinase"],"prefix":"10.1128","volume":"188","author":[{"given":"Andrea K.","family":"White","sequence":"first","affiliation":[{"name":"Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Hoch","sequence":"additional","affiliation":[{"name":"Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Grynberg","sequence":"additional","affiliation":[{"name":"Infectious and Inflammatory Disease Research (IIDC), The Burnham Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Godzik","sequence":"additional","affiliation":[{"name":"Infectious and Inflammatory Disease Research (IIDC), The Burnham Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Perego","sequence":"additional","affiliation":[{"name":"Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.81.5.741-746.1961"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(91)90495-W"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1046\/j.1365-2672.1998.00405.x","volume":"84","year":"1998","unstructured":"Baillie, L., A. 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